Dr. Kerr, I presume?
Clark Ellis brings us a rare interview with British researcher Dr. Jonathan Kerr who is now living in Colombia.
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Allergy / Mast cell treatments

Discussion in 'Mast Cell Disorders/Mastocytosis' started by xchocoholic, Aug 25, 2012.

  1. triffid113

    triffid113 Day of the Square Peg

    I am a terribly allergic person and totally unschooled about all of this. But one thing jumps out...your mentioning that blah blah raises IgE. Did you know that ZINC lowers IgG?


    Biomedical and Life Sciences


    Volume 22, Number 6 (2009), 1031-1040, DOI: 10.1007/s10534-009-9254-z

    Comparison of inhibitory activities of zinc oxide ultrafine and fine particulates on IgE-induced mast cell activation

    Kouya Yamaki and Shin Yoshino


    The effects of ultrafine and fine particles of zinc oxide (ZnO) on IgE-dependent mast cell activation were investigated. The rat mast cell line RBL2H3 sensitized with monoclonal anti-ovalbumin (OVA) IgE was challenged with OVA in the presence or absence of ZnO particles and zinc sulfate (ZnSO4). Degranulation of RBL2H3 was examined by the release of β-hexosaminidase. To understand the mechanisms responsible for regulating mast cell functions, the effects of ZnO particles on the levels of intracellular Zn2+, Ca2+, phosphorylated-Akt, and global tyrosine phosphorylation were also measured. IgE-induced release of β-hexosaminidase was obviously attenuated by ultrafine ZnO particles and ZnSO4, whereas it was very weakly inhibited by fine ZnO particles. The intracellular Zn2+ concentration was higher in the cells incubated with ultrafine ZnO particles than in those with fine ZnO particles. Consistent with inhibitory effect on release of β-hexosaminidase, ultrafine ZnO particles and ZnSO4, but not fine ZnO particle, strongly attenuated the IgE-mediated increase of phosphorylated-Akt and tyrosine phosphorylations of 100 and 70 kDa proteins in RBL2H3 cells. These findings indicate that ultrafine ZnO particles, with a small diameter and a large total surface area/mass, could release Zn2+ easily and increase intracellular Zn2+ concentration efficiently, thus decreasing FcεRI-mediated mast cell degranulation through inhibitions of PI3K and protein tyrosine kinase activation. Exposure to ZnO particles might affect immune responses, especially in allergic diseases.


    The reason I can't relate to the H1 H2 receptor discussion is that I refuse to take drugs (ESPECIALLY PPI inhibitors which I am convinced are the real reason my father passed on). I am extremely sensitive to drugs and so I cannot take them. But turning off your stomach acid production IMHO is ALWAYS a mistake. And fyi I have NEVER SEEN these things prescribed after ACTUALLY testing stomach ph...it is always ASSUMED that if the stomach hurts, then it is too much HCL (when in fact it may be too LITTLE). DO you know that PPI inhibitors have been proven to cause contraction of CDIFFs if the germs are present (whereas people with sufficient HCL do not get CDIFFs). HCL is the body's main defense against pathogens entering through the digestive tract.
  2. triffid113

    triffid113 Day of the Square Peg

    I typed a long article about the Weston Price article about oxalates which says quite a bit about CFS but I somehow lost it. Here's the article if interested: http://www.westonaprice.org/food-features/the-role-of-oxalates-in-autism-and-chronic-disorders

    It says you can get oxalates from yeasts and fungi, such as Candide [which says to me the primary problem is low HCL, because adequate HCL prevents Candide overgrowth].

    Here is an exerpt:

    Yeast is a common factor in chronic fatigue and fibromyalgia, and antifungal therapy is very useful in treating these problems. Jacob Teitelbaum has written several books about the treatment of fibromyalgia and indicates two-thirds of individuals improved their chronic fatigue and fibromyalgia after anti-fungal therapy.

    A Dr. Eaton in England found that individuals who had chronic fatigue would actually produce alcohol from their sugar intake. He describes patients who would do a baseline blood-alcohol test, then take some glucose dissolved in a flavored drink, and measure the blood alcohol one or two hours later. The blood alcohol would be substantially higher if the person had a severe Candida problem.
    Eaton found that by using this test he could monitor patients undergoing different treatments for chronic fatigue and fibromyalgia and found that 42 percent of patients improved just with sugar restriction alone. If he combined a low-sugar diet together with anti-fungal drugs, he had about a 78 percent success rate.

    The most comprehensive study was that of a Dr. Jessop in California, who treated over one thousand people with chronic fatigue and fibromyalgia using a single anti-fungal drug, ketoconazole. Eighty-four percent of the patients improved. Of the 1,100 patients, 685 were on disability payments. After the treatment with anti-fungal treatment, only twelve remained on disability. It was an extremely effective treatment!

    It says people who eat soy or spinach as main dishes on a daily basis are pretty much going to have stones. But here are mitigating strategies that taken together with limiting oxalates can largely prevent stone formation:

    The most effective way to get rid of oxalates is the use of calcium citrate. This supplement exerts a double potency action in eliminating oxalate. The calcium part of calcium citrate binds to the oxalate and causes it to precipitate out in the stool so it will not be absorbed. But part of the oxalate escapes. The citrate is a second line of defense, which competes directly with the oxalate for absorption.

    For the treatment to be effective, the calcium citrate must be taken at the same time as the oxalate-containing food. If you have problems with any of conditions caused by oxalates—kidney stones, autism or vulvodynia— then taking calcium citrate with each meal can be very effective. If there is an adequate amount of calcium in the diet—if supplementing with calcium citrate, for example—it will combine with the oxalate in the GI tract, precipitate out in the stool, and then be eliminated in the stool.

    The optimum dosage is approximately 300-350 mg calcium as calcium citrate for a total of 1000 mg (one gram) of calcium a day. If you’re taking this you don’t need additional sources of calcium. An even better approach would be to use magnesium citrate. The adult dosage is about 300-400 mg a day. Some practitioners recommend up to 1000 mg but many people report problems with diarrhea if they exceed 400 mg. Again, a divided dose would be best, taking the magnesium citrate with each meal.


    Lastly it says that the problem with oxalates is that they cause the urine to become a very low ph (acidic). Now I have the VDR mutation and I found that pretty much nothing would budge my urinary ph until science discovered that 400IU was nowhere near enough D. I found the single thing most affecting urinary ph is Vitamin D status (which governs ability to absorb calcium). I don't remember which way it makes the ph go. But I would STROGLY suggest a Vitamin D test. I maintain my D levels at 70 (not 50) and I was only at 25 before I started taking 50,000 D/week by prescription. You can buy ph test strips and check your ph. If I was a stone former I would.
  3. Fogbuster

    Fogbuster Senior Member

    I have tried to search if Fluoxetine has been proven to be effective at helping mast cell issues in studies. Has it? As when I took it my "wired" symptom and "reaction" to foods etc was significantly reduced. Utterly convinced I have MC issues..

  4. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

    Czechosherlockia, USA
    IIRC, Prozac was developed from Benedryl/diphenhydramine.

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