Excluding the misdiagnosed patients, I think it's safe to assume that most of the CCC diagnosed ME patients have at least one common denominator. In my opinion, the way to get the best clues as to what can lie behind this disease is to try to answer the following question. Pieces which must fit the puzzle: 1) Mononucleosis, giardisis and the flu are among triggers for the disease. What can be triggered by so wildly different things such as the aforementioned infections? 2) If the Mella/Fluge results hold true, that what, has to be able to cause symptoms mediated via autoimmunity/autoinflammation – further narrowing the list of possible suspects. 3) The cause(s) leading to ME has to be more prevalent in women than men. 4) What's causing the disease must be able to produce a wide array of symptoms (brainfog, joint paint, visual problems, fatigue etc). If you have any other things you'd like to add to the list, then please do weigh in. The only candidate I know of, which fulfills the four criteria, are ERVs. Does anyone else know of other viable candidates? I recently stumbled across these graphics from the company of which Perron works for. It pretty much falls in line with everything I've thought about how ME erupts: I find it really hard to believe that a exogenous retrovirus can be the culprit of the disease, when we know all too well how mononucleosis, giardisis or a flu (and more things which are pretty unrelated) can trigger the disease. (see an article about Perron's work here) I am hoping we can get a debate going about this in the weeks to come. I'm working on getting a list ready for early March, which will be discussed with a person who's got several hundred thousands of dollars disposable, which can be used for ME research. My health is really frail, so I wont pop by daily to the forums, but please do drop some lines if you've got some thoughts on the matter. Both on what pieces must fit the puzzle, and also on possible candidates matching that list.