A few months ago, my doctor tested me for MTHFR. I came back homozygous for 677T, and she started me on a regimen of 1000 mcg methylcobalamin, tapered up to 5000mcg over a month. Then I started taking 400mcg methylfolate and tapered up to 800mcg over a month. During that time I started feeling incredibly toxic. My muscles were sore, I couldn't exercise because I was so tired, and I cried multiple times per week which was extremely unusual for me (having never really cried much in my life). After two months, I stopped the supplements and felt better the next day. During that time I did some research and got my genes tested by 23andme using the v4 chip. Here are some of my results: VDR Taq +/- MAO A R297R +/+ MTHFR 677T +/+ MTRR A66G +/- MTRR K350A +/- BHMT-02 +/+ BHMT-08 +/+ ACHY-01 +/- ACHY-19 +/- After getting these results I started on Rich's protocol, taking the following supplements early in the morning: 2000mcg hydroxocobalamin 200mcg methylfolate Yasko's All-in-One (1x) Yasko's BeCalm spray (6x) Yasko's Phosphatidyl Serine Complex (1x) Vitamin D 4000 IU It has been about two weeks since I started. I feel good in the mornings, but I crash about 8 hours after taking my supplements. For the next 6 hours until bedtime, I become extremely fatigued, sad (often wanting to cry), unable to move around much, and my brain gets foggy and I have difficulty stringing thoughts together. Sometimes I have difficulty speaking properly -- I mispronounce words or combine multiple words together. That never happened to me before starting the protocol. I would be grateful for any help figuring out what is causing this afternoon crash, and whether or not my current protocol makes sense based on my genetic mutations.