Dear everyone! I am happy to be able to say that I am finding some results after reattempting methylation supplementation! I am here to find out how to continue this by beating side effects I am now experiencing from "revving" my cycle. I have known about methylation and have had my SNPs since about 3 years ago. I'm male, 29 years old. Genetic Genie: http://tinyurl.com/ogjcxh6 Detox: http://tinyurl.com/olpxday MTHFRsupport full report (49 pages of SNPs): http://tinyurl.com/o893a8w I wrote here, maybe a year ago, that I was struggling with side effects and that the fear of feeling totally edgy or flat as a board was just too much to continue. But I enlisted the help of a naturopath trained in methylation genomics, and I've found a new approach (teaser: it's DAO) that has allowed me to "rev" the methylation cycle a bit and be able to tolerate it! Unfortunately, after many months and around $1000 dollars later I had to fire my naturopath for... I guess the best word is negligence... I'll explain, but the take away is that I am for the moment managing this on my own. Here's the rundown: I should first note I have psychiatric issues. Most of what I struggle with are psychiatric symptoms when trying to tweak my methylation. I'm on lithium, Seroquel (both of these at "sub-theraputic" doses) and klonipin. I suffer from nerves and edginess, and if I'm not on Seroquel I become psychotic. COMT and MAO A. I am not looking for advice on what to do about those meds at this time Skip further to the bottom for my bullet points if you don't have the time to read the whole thing For the majority of 2014, I was supplementing with: 1 every other day of Seeking Health (Dr Lynch) B Minus (b complex without folate, without b12) 3-4 x day of New Chapter Turmeric Force 1 x day 1000mg grocery store brand Vit C 1 x day 25mg zinc 1 x day 2000 iu store brand Vit D (near the end of the year was reduced to 1000 iu, felt better I think) This is what I was taking under the supervision of my naturopath. Take note of what I was NOT taking anymore: 2 x day 50mg P5P 1 x day B Minus complex 1 x day New Chapter Turmeric Force Histame (here's the DAO. Explanation about dosing to follow below) It's a simple list. I felt my naturopath to be competent, so I followed her treatment plan to a T. This meant that if she didn't include previously used supplements, I assumed it was because that was part of the plan. I sought out her help at about mid February because I started to have a terrible time dealing with the unprecedented allergy season experienced here on the east coast of the USA (specifically the mid Atlantic where I live). She had me get a methylation report through MTHFRsupport.com, 49 pages of SNPs (you can find them in my signature and I will link at the end). She identified multiple homozygous DAO mutations, and suggested I try a DAO enzyme. But the complications of how my body reacted to DAO and the amount I ended up taking initially became extremely tough to deal with. My naturopath did not give me a dosing recommendation when she suggested I try DAO. Through my knowledge gained working at a supplement store I understood that digestive enzymes did their work in the gut, and that I would just expect some effect similar to something like Allegra, but perhaps with less side effects. So after trying 1 pill and feeling ok the next day, I tried 2. Then started to work my way up to what the bottle recommended (2 x meal, so 6 x day), because it seemed harmless. Long story short, I after 2 weeks on DAO (Histame) I had had a honeymoon period of great mood and improved functioning, but swung further into mania, bizarre thoughts and then to the precipice of panic. I have since stabilized. This took a long time, and I had some moments where I thought I was never going to escape a maddening pattern of nibbling on a slice of orange to counteract DAO, or to add DAO or an herbal tincture to reduce histamine. It was a dark time, but there was a positive takeaway: I had a change in my quality of emotional and mental state of mind. During this time I learned the importance of histamine in not only methylation, but mood/catecholamines. Despite the horrible journey out of the wacked-out histamine balance, I felt that lowering my histamine load had done something (read: free up my methyl groups) I could take advantage of. Unfortunately, my naturopath was unable to take advantage of this, and I felt like my time was being wasted, so I fired her. And here I am, back in charge of my sometimes fragile health. And the good news is that I am already experiencing success! Here is what I'm taking now: 1 x day molybdenum (dose has changed, took too much to soon already) 1 x day a nibble (literally crumbs!) of whole food B complex including folate and B12 (Innate B Complex) 1 x day 1/8 Histame (so sensitive, I have to divide the capsules this small!) 1 x day Dr Lynch's B Minus 2 x day 50 mg P5P Low histamine diet! I have found that if I keep the folate and B12 supplementation low, drink electrolytes with them and perhaps with molybdenum's help, I am further improving my methylation. I have CBS mutations so I have chosen that to be my first target. I experience better quality of thought, more pep, and better mood. I can tell though, that more needs to be done. Doing the same thing today doesn't bring as much of the effect that I had when starting this regimen 6 days ago Side effects of folate and b12 supplementation so far: Edginess and agitation - can improve with electrolytes, extra P5P, or BCAAs to deplete serotonin and dopamine (though this can leave me numbed). I know that niacin can slow down methylation, but I have not used it to do so yet. I wonder if that's really better than these other options. I think I now may be experiencing some of the droopiness or numbness that I've felt before taking folate. I also started molybdenum around the same time, and I hear that I can have a hard time with detox. That might be happening already So, to cap off my post... What do I do next to improve my methylation? I have my ideas: Glutathione is the next item on Dr Ben Lynch's list of remedies for methylation side effects, what do I need to know if I am to try it? My naturopath told me that NAC should be taken with it. Why? I am not taking vitamin D, but I feel it important. I have been deficient before (I havn't had a test done in some time). What do I need to know with my VDR mutations? Zinc is missing from my "stack", and I suspect it would be good to have on board. What should I watch out for, if anything? Copper - I am curious about a potential deficiency. I desire to take a blood test. I understand this can be tricky, what suggestions do you have? Anyone with experience? L-Ornithine is the next item I have on my list to try, because of it's action of the urea cycle. What should I know as possible dangers? What are your ideas? That's plenty right there. Again my SNPs are in my signature. Let me know if I can help any of you in any way, I have a lot of knowledge about psychiatric issues in general, meds, many herbs and supplements from having worked in a quality shop for a while!