I am about to do something drastic - I just don't know exactly what..? After almost two years on the methylation protocol, I am still struggling to get it right. I feel like I've been missing something very fundamental all this time. I have tried to be a good sport and have pushed up my daily doses to about 7 mgs of methylfolate and 15.20 mgs of MeCbl. I have stayed on this level for at least the past 6+months....sometimes I am doing alright, but most of the time I'm not. This is how it goes; When I get up in the morning, if it's been a reasonably good night (I have insomnia+two small kids that frequently wake me up) I can sometimes feel quite alright. Then, on an empty stomach, I start taking 5mgs of MeFolate, some Carnitine (mostly CarnitAll yealding 600mgs of Alcar fumarate) with a drink containing ca 500mgs L-methionine and Ribose, sometimes v little TMG. After 30-60 mins I add in 5 mgs sublingual MeCbl, sometimes some sublingual NADH (about 25 mgs + 100-150 mgs CoQ10) and after that I'm done for. Zonked out for most part of the day. The initial energy and mental clarity I felt I had before taking these supps vanish completely and is replaced by massive brainfog, muscle weakness, fatigue and sometimes slight tremours/hands trembling. I have tried adding more niacin = no effect, I have tried adding potassium = no effect, I have tried adding salt+potassium = no effect, I have tried to add much more MeCbl = no effect. Like I said; I still take 7-8 mgs of methylfolate daily (divided dose, twice/day) and 15-20 mgs MeCbl (sublingual, and every third day as transdermal injection). With my second, midday dose of 2 mg Me-folate I also take an additional 250mg Carnitine, and of course, more MeCbl with that. But this does not make a difference. I'm still in the fog, the deep, deep fog. Me being homozygous for MTHFR 1298C and MTRR, (with ME/CFS) it is perfectly logical to me I need to supplement with MeFolate and MeCbl, the question is...how much? and how? and when? And - why is it making me feel so bad....?! I need to make some change, apparently, to tweak the protocol in some direction....I just do not have any idea how...where to start. I should mention a few things; I take a daily low-dose B-complex (Douglas Labs at moment). I am NOT taking supplemental folic acid or cyanoCbl. I probably get a fair amount of 'natural folates' from veggies, have never tried to limit this. I sometimes exchange the MeCbl for AdCbl, no change when it comes to 'side-effects'. I have improved during my 2 years on the protocol, various symtoms have diminished and over-all increased functionality, however, still suffering from extreme fatigue, brainfog, weakness.....I do not identify with the listed signs associated with potassium loss, paradoxical folate insufficiency and/or over-methylation. I do not have anxiety or heart-palpitations or angular chelitis or acne-type leasions. None of that. Just a complete and numbing lack of energy. All day, every day. Does anyone here recognize this? Thanks so much for your attention!