BMJ: Aerobic work capacity in patients with chronic fatigue syndrome. 1990. OBJECTIVE--To determine the aerobic work capacity of patients with the chronic fatigue syndrome and compare it with that of two control groups, and to assess the patients' perception of their level of activity before and during illness. They wrote in the study: "In summary, patients with the chronic fatigue syndrome who impaired capacity for exercise despite an increased perception of their exertion. We found no evidence for a deficient cardiovasculat response or peripheral muscle function other than that which would be expected as a result of deconditioning. Other mechanisms, however, such as atrophy of muscle fibre or depletion of muscle enzymes may result in similar findings and merit further investigation". The Berlin wall had just been demolished. The year was 1990. The Soviet Union was still a country. It was 27 years ago. It was the year I was born. Why on earth didn't one continue this track? What the f*** happened? It looked like they were on the right track back then. Many interesting studies from the late 80's and early 90's. If our symptoms are caused by dysregulation of the enzyme PDH it is all tragicomic. Patients say that they have no energy. Patients say that they feel lactic acid just by standing up, or just by walking a few metres. Can a enzyme crucial for energy be why we can't use utilise energy? Why investigate that in-depth when one can destroy the path where science was headed with some stupid papers on CBT? Why listen to patients when you can choose not to? Why would having a proper functioning of the energy metabolism be worth investigation further when you can choose not too? I don't know if how close we are, but one thing is certain: ME will be one the darkest stories in the history of modern medicine. Lets hope that 2017 will be the year things started really to change.