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ADVICE? TREATING COMT V158M COMT H62H MAO-A R297R

Discussion in 'Genetic Testing and SNPs' started by tsb88, May 15, 2015.

  1. tsb88

    tsb88

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    I have recently received 23andme results. Its so overwhelming on where to begin! I have a long history of anxiety, stress and brainfog, although I have a high IQ. Does anyone out there have experience in this? What supplements are recommended? I picked out the main offenders... looking to treat the following mutations:

    HOMO:
    COMT V158M AA
    COMT H62H TT
    MAO-A R297R TT

    Any help at all would be VERY greatly appreciated! THANKYOU [​IMG]
     
  2. tsb88

    tsb88

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    Also Hetero in both main MTHFR Snps if that helps. Trying to get my head around this methylation business. Can provide more results if need be. Desperate for guidance. Anyone know of any experts in this area in Australia? (Not just specifically MTHFR) Thanks again
     
  3. Gondwanaland

    Gondwanaland Senior Member

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    Magnesium for COMT and vitamin B2 for MAO-A. Plus check your thyroid!
     
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  4. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    Someone posted about a Dr on Gold Coast. You might have better luck starting a thread asking for Aussie MD.
    I'm linking 3 threads w/ discussions re MAO, COMT. I'd been trying to get on top of MAO for a year, it's my sole homo SNP. I've now been using the FMN mentioned in these posts for almost 2 weeks. I've found it's made a big difference in my experience of oxidative stress, therefore overall level of well-being.

    http://forums.phoenixrising.me/inde...lation-protocol-srmp.36344/page-2#post-586710

    http://forums.phoenixrising.me/index.php?threads/is-taking-bh4-a-problem-for-comt.36997/#post-588606
     
  5. TheChosenOne

    TheChosenOne Senior Member

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    There is a very good talk by dr Yasko about COMT:
    What I take is niacinamide (500 mg in the morning) and magnesium. I also take D3 for VDR Taq.
    Lithium should also be inlcuded.
     
  6. Kathevans

    Kathevans Senior Member

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    Boston, Massachusetts
    @ahmo Your first link above leads to an "Error" for me. (Might be my iPad) I'm thinking that might relate to COMT, which I'm interested in knowing more about, particularly its relationship to magnesium. I've increased my magnesium over the last year--both citrate and malate--and feel it has improved sleep and possibly other issues...

    I've been following MAO discussions and have the FMN on order. Thanks!
     
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  7. Gondwanaland

    Gondwanaland Senior Member

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    ahmo likes this.
  8. Kathevans

    Kathevans Senior Member

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    Oh, this old thread! (Thank you, @Gondwanaland!). I'd drifted away from it after those high potassium bananas! I'm not a naturally scientific person--that was my Dad--so I really have to be concerned about something to put in the effort to understand it deeply. Of course, some of these bodily reactions have been taking me down that road lately. There's a lot of fascinating--and quite relevant to my SNPs--info in that thread... I'll be spending more time with it, I'm sure.
     

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