1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Ergonomics and ME/CFS: Have You Hurt Yourself Without Knowing It?
Having a chronic illness like ME/CFS can make it hard to avoid problems that come from bad ergonomics. Jody Smith has learned some lessons the hard way ...
Discuss the article on the Forums.

Adrenaline surges?

Discussion in 'Hormones' started by Lucinda, Aug 16, 2010.

  1. Jeffy14

    Jeffy14

    Messages:
    47
    Likes:
    0
    Hello,

    Thanks for your answer.
    I bought 5htp and Gabba to try it out when I'm wired :)
    Also, yes paracetamol is a painkiller but it really puts me asleep.
    When I'm really wired, I take 1g but it usually does not work and I wake up in the next hour so when I wake up I take another 1g.
    It really makes a difference for me.
    They also sell Ibuprofen or paracetemol (advil PM or tylenol PM)+ Diphenhydramine.
    Diphenhydramine puts you asleep but I noticed I have a lot of troubles to wake up the next morning. Yes you fall asleep but the next morning you still fell asleep for long hours...
    Give it a try, maybe it's different for you.
     
  2. Lucinda

    Lucinda Senior Member

    Messages:
    109
    Likes:
    9
    UK
    Yes I'm familiar with Diphenhydramine. It is in 'Nytol' which is an over-the-counter sleeping pill in the UK. I do take it at night sometimes, and I do find it helps me sleep as long as I'm not too 'wired' and as long as I don't take it too early. I also can't take it often else it stops making me sleep and just makes me feel awful instead!

    I would say it's my favourite of the non-prescription sleep meds though. I don't have troubles waking up after taking it. However I do have that trouble with another antihistamine - Promethazine Hydrochloride. This is in 'Sominex'. It makes me sleep for ages, and when I finally wake up, I'm totally wiped out for the rest of the day and usually have to stay in bed most of the day. However this is quite useful occassionally when I am very over tired due to lack of sleep. Last time I took it I slept for 15 hours!!! And even after that I had to spend most of the next 24 hours in bed. I was really overtired though.
     
  3. Lucinda

    Lucinda Senior Member

    Messages:
    109
    Likes:
    9
    UK
    I was talking to an acupuncturist online about this 'wired' problem, and she says it can be caused by an overactive immune system.

    This interests me as ever since developing this problem, I haven't caught virus'. Even if everyone in my house has a cold or whatever, I don't get it. When before I had ME, I caught loads of virus'!

    I don't know much about the immune system though. Does anyone else think this problem with feeling wired/restless/unable to relax could have something to do with an overactive immune system? And what can a person do to calm this down?
     
  4. SickOfSickness

    SickOfSickness Senior Member

    Messages:
    1,848
    Likes:
    929
    US
    I think it's because of the body being stressed. By things that shouldn't be difficult, but they are for us. Like walking up stairs, or more basic movements. Also because of hormones and how we usually get into a perpetual bad cycle with sleep problems (then the sleep causes hormone and other problems).

    In my case I have a very overactive "fight or flight" system which gets easily triggered and is harder to calm down. I don't think we all have the same problems but usually have 2 or more out of the main list of symptoms.

    I do think I have an overactive immune system too but I get sick easily, the opposite of you. I think I have one or more HGRVs making me sick, causing my immune system to be struggling, but it's an uphill battle. I think my immune system is confused and attacks too many other things, which causes me difficulty.
     
  5. nanciswell

    nanciswell

    Messages:
    59
    Likes:
    4
    I used to get major surges . Now with eliminating the foods and chemicals that I am sensitive they are better. So I avoid many things as I am super responder , being intolerant of amines, salcylates, gluten, sulfur foods, sulfites to name a few.

    I take homeopathics for my adrenals. The most beneficial so far has been homeopathic of the hypothalamus. This helps my heart, stops my sweating due to poor adrenals , as well as calms and balances my energy,,,

    nanci
     
  6. richvank

    richvank Senior Member

    Messages:
    2,717
    Likes:
    756
    Hi, Jeffy14.

    I just want to encourage you to be careful with paracetamol (APAP, acetaminophen, or Tylenol in the U.S.). This drug depletes glutathione in the liver if taken at high dosages. Overdose of this drug (sometimes intentionally, but not always) has been reported to be the main cause of the need for a liver transplant.

    Best regards,

    Rich
     
  7. richvank

    richvank Senior Member

    Messages:
    2,717
    Likes:
    756
    Hi, all.

    I want to add something to what I wrote before about the biochemistry of the condition that is the subject of this thread.

    As I noted, the astrocytes in the brain normally import glutamate from the synapses of the neurons, and convert it to glutamine. Then they export it back to the neurons, so that they can use it to make glutamate again. If this recycling does not happen rapidly enough, glutamate builds up in the synapses, and that causes the neurons to fire too rapidly, which is what is involved in causing excitotoxicity. I described a possible cause of this, namely depletion of glutathione, which lowers the rate of production of ATP, which is needed to power the importation and the conversion of glutamate.

    Another possible cause of excitotoxicity might be a deficiency of manganese. The reason is that manganese is a cofactor for the enzyme that converts glutamate to glutamine, which is called glutamine synthetase. Manganese deficiency can be detected with a blood test.

    Best regards,

    Rich
     
  8. Enid

    Enid Senior Member

    Messages:
    3,309
    Likes:
    840
    UK
    Thanks for all that Richvank very useful indeed in understanding - and appropriately addressing.
     
  9. Fogbuster

    Fogbuster Senior Member

    Messages:
    119
    Likes:
    43
    Anyone found an answer or reasonable explanation as to what is causing the "adrenaline surges"?

    For me I feel it's caused by or goes hand in hand with OI. The more I stand still, whilst standing, the worse the wired full body adrenaline surge becomes.

    The same symptom occurs if I have a cigarette, which leads me to think it could be adrenals causing the problem. Then again I've had an adrenal stress profile which has come back normal. Rich's theory is very interesting.

    So, ultimately has anyone had any success with tackling this horrible symptom?
     
  10. SickOfSickness

    SickOfSickness Senior Member

    Messages:
    1,848
    Likes:
    929
    US
    That is known to happen, the body is trying to compensate for being upright. Sorry I don't have a detailed explanation.

    Most ME/CFS patients have OI and low blood volume, 80% of normal.
     
  11. SickOfSickness

    SickOfSickness Senior Member

    Messages:
    1,848
    Likes:
    929
    US

See more popular forum discussions.

Share This Page