Can anyone explain how Weight gain and adrenal fatigue are related. As I understand it those with adrenal fatigue can gain fat around the middle, but that kind of weight gain is associated with high cortisol levels. So if the adrenals are weak then how can this kind of weight gain occur? I know adrenal fatigue can through out the timing of many hormones but it still doesn't explain why high cortisol related weight gain occurs. Even if cortisol was unusually high at the wrong times (for one period in the day) would that be enough to make you gain fat around the mid-section? Can anyone explain this?