Hydrocortisone will not fix ME/CFS and should not be administered without appropriate testing. If anyone expects a miraculous recovery from hormone replacement, they will likely be disappointed. But for me, significant reduction of symptoms such as fatigue and pain and a return to life out of bed have been *enough*. There are no well designed current studies aimed directly at this issue. No one wants to fund them because there are no financial benefits. No one wants to talk about the benefits of low dose (defined by conventional medicine as less than 40 mg of HC per day) steroids because everyone gets nervous about adrenal suppression. But doctors ARE using them in their practices because they realize that it is a Goldilocks problem - too little is just as much of a problem as not enough. And other doctors are trying to treat the underlying brain dysfunction, and other doctors try to use herbal remedies to avoid the stigma of steroids. It would be amazing to have a one-size fits all solution, but it is unwise in my opinion to discount the anecdotal evidence of many patients who have been helped by steroids by discounting them based on antiquated research that is limited in scope at best. DHEA has been shown conclusively to benefit patients with Addison's when levels are low. I personally have also benefited from raising my DHEA levels from 6 to around 150. My eyes were so dry that I spent a fortune on drops before DHEA. I rarely use them anymore and that is just one benefit.