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Adipose tissue as a dedicated reservoir of functional mast cell progenitors

Discussion in 'Mast Cell Disorders/Mastocytosis' started by nanonug, Nov 19, 2012.

  1. nanonug

    nanonug Senior Member

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    Virginia, USA
    1. Stem Cells. 2010 Nov;28(11):2065-72. doi: 10.1002/stem.523.

    Adipose tissue as a dedicated reservoir of functional mast cell progenitors.

    Poglio S, De Toni-Costes F, Arnaud E, Laharrague P, Espinosa E, Casteilla L,
    Cousin B.

    CNRS, UMR 5241 Métabolisme, Plasticité et Mitochondrie, Université de Toulouse
    III Paul Sabatier, Toulouse, France.

    White adipose tissue (WAT) is a heterogeneous tissue, found in various locations
    throughout the body, containing mature adipocytes and the stroma-vascular
    fraction (SVF). The SVF includes a large proportion of immune hematopoietic
    cells, among which, mast cells that contribute to diet-induced obesity. In this
    study, we asked whether mast cells present in mice adipose tissue could derive
    from hematopoietic stem/progenitor cells (HSPC) identified in the tissue. We
    therefore performed both in vitro and in vivo experiments dedicated to monitoring
    the progeny of WAT-derived HSPC. The entire study was conducted in parallel with
    bone marrow-derived cells, considered the gold standard for hematopoietic-lineage
    studies. Here, we demonstrate that adipose-derived HSPC contain a precursor-cell
    population committed to the mast cell lineage, and able to efficiently home to
    peripheral organs such as intestine and skin, where it acquires properties of
    functional tissue mast cells. Additionally, WAT contains a significant mast cell
    progenitor population, suggesting that the entire mast cell lineage process take
    place in WAT. Considering the quantitative importance of WAT in the adult
    organism and the increasing roles recently assigned to mast cells in
    physiopathology, WAT may represent an important source of mast cells in
    physiological and pathological situations.

    Copyright © 2010 AlphaMed Press.

    PMID: 20845475

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