I recently saw an article come through the Prohealth site that talks about B-12 deficiency specifically. http://www.prohealth.com/library/sh...=EP021811&slvor=10595.103322.214.171.124.14790&eid It says that Adb12, besides being essential for energy metabolism, is required for the normal myelin sheath formation and nucleoprotein synthesis plus Adb12 deficiencies are associated with nerve and spinal cord degeneration. I hadn't heard that before regarding Adb12, only with MethyB12, but it was interesting to me because I started taking Adb12 alone in the summer and found it to be very helpful. Not only did it help my energy levels but greatly reduced pain. I've had pain for about 20 yrs now, worsening after whiplash 10 yrs ago. While in my 20's I was dx with degenerative disc disease and my spine has always been a problem. There are also 2 cases of MS in my family, both having symptoms occur by 50 yrs old. I've asked previously why the Adb12 helped me so much with pain, and Rich gave his opinion http://forums.aboutmecfs.org/showthread.php?188-B-12-The-Hidden-Story/page166 I'm just curious to hear what people think of this article and if it's feasible that the Adb12 helped because it's involved with 'healing' the myelin sheath/spinal cord as well. The article also mentions that MethylB12 helps with circadian rhythm and FWIW since taking MethylB12 I have been able to sleep 8 hrs a night and at 'normal' bed/wake time for the first time in many many years. Unfortunately I've recently started to have a niacin type flush reaction to the methylB12, and reduced the dosage. I hope it's not a long-term problem.