@caledonia @ahmo @Freddd Last Friday I put my 23andme results through Sterling's app, and got a ton of new info - most of which I don't know what to do with (but I'm researching). There are a few pages of these charts at the end of the report, and this one is for the transulfuration pathway. What I found to be really interesting is that it says that one of the co-factors for this pathway is adeno-b12. I am starting to explore Fredd's information more, and have been feeling called to try the adeno-b12. I have really been struggling with the transulfuration pathway, and what I have been trying hasn't been clearing it. I'm wondering if the adeno b12 is what allows people to tolerate higher amounts of methylfolate.... (I apologize, Fredd, if you've already posted about this somewhere...I'm navigating the forums the best I can ) I haven't seen any information anywhere about adeno b12 and the transulfuration pathway... Has anyone else?