Rich Von Konynenburg believes low glutathione levels are key in ME/CFS. I am not at all sure. This study found, interestingly enough, that both manual and electric acupuncture increased glutathione levels in the muscles of laboratory rats and that manual acupuncture also increased carnitine levels. Some studies have found increased rates of oxidative stress in the muscles of ME/CFS patients. If that's true then you definitely want more GSH in there to mop up those free radicals. Evid Based Complement Alternat Med. 2009 Jul 10. [Epub ahead of print] Links Investigation of Electroacupuncture and Manual Acupuncture on Carnitine and Glutathione in Muscle. Toda S. Department of Health Sciences, Kansai University of Health Sciences, 2-11-1 Wakaba, Kumatori, Sen-nan, Osaka-fu 590-0482, Japan. firstname.lastname@example.org. Maybe the people who where helped by acupuncture had low glutathione(?). Or maybe they just had a better acupuncturist. Or maybe it was something else.