@ahmo I enjoyed reading your string of posts in this thread. Your evolution of thought concerning dosages was very similar to mine. If I have any symptoms whatsoever, my first thought now is to ramp up the folate, and it seems to work. In times of stress I'll also increase the dosage in anticipation of the need. I don't even wait for the symptoms now. I caught this disease early so it was probably easier for me than most here. I feel absolutely recovered. although I am battling a bit of numbness in my toes. I've been able to work 10 hour days for the past two months surviving on 9.6 mg folate, 24 mg mb12, 3 mg adb12, and 1mg L-carnitine. This would have been impossible 2 years ago without the supplements. Anyway, just wanted to second your voice about larger dosages.