Hi, I mentioned this problem in another post on this forum (in connection with my methylation problems - i have the CBS A360A and MTRR / A66G mutations) but have never really gotten to the bottom of why so many things cause my skin to break out. Just about anything these days gives me acne - certain vitamins and supplements (Omega fatty acids, amino acids, probiotics), certain foods such as eggs, too much dairy/milk products, any sort of detox regime/lymph drainage, lysine, even drinking hot lemon with water...the list goes on and on!! This has only become a real issue over the past few years as i don't recall overreacting to so many things in the past. Years ago i was told that i have pcos (and that this is the cause of my acne), but my hormones have been tested many times over the past few years and my androgen levels are always within the normal range (although my DHEA and Cortisol are quite low, estrogen and prog are normal but bit low). I have been wondering whether i am over methylating or even under methylating (some sort of homocysteine problem) perhaps and that this is why i over-react to so many things... A recent Metabolic Analysis Test revealed deficiencies in folic acid, B12 (and B2 and B6) and some people on this forum have said that low folic acid levels can cause acne. I tried taking B2 and B6 and hey presto my skin broke out again!!! I have also read on Ben Lynch's forum that Niacin is helpful to stop the over methylation process....but am not sure whether i should try this out given i am so sensitive. Any thoughts on the above would be very welcome!! I may post this in the hormone section too but wanted to try here first.