Invisible Illness Awareness Week 2016: Our Voices Need to Be Heard
Never heard of Invisible Illness Awareness Week? You're not alone. Jody Smith sheds a little light to make it more visible
Discuss the article on the Forums.

Acid reflux drug linked to more than doubled risk of stomach cancer – study

Discussion in 'Other Health News and Research' started by Ecoclimber, Nov 2, 2017.

  1. Ecoclimber

    Ecoclimber Senior Member

    Messages:
    988
    Likes:
    2,424
    Acid reflux drug linked to more than doubled risk of stomach cancer – study


    There are more than 50m prescriptions for proton pump inhibitors in the UK, though they have previously been linked to side-effects and increased risk of death

    A drug commonly used to treat acid reflux is linked to a more than doubled risk of developing stomach cancer, researchers have claimed.

    Proton pump inhibitors (PPIs) reduce the amount of acid made by the stomach and are used to treat acid reflux and stomach ulcers.

    A study published in the journal Gut identified an association between long-term use of the drug and a 2.4 times higher risk of developing stomach cancer. In the UK, there are more than 50m prescriptions for PPIs every year but they have been linked to side-effects and an increased risk of death.

    A link between PPIs and a higher stomach cancer risk has previously been identified by academics – but never in a study that first eliminates a bacteria suspected of fuelling the illness’s development.

    Research by the University of Hong Kong and University College London found that after the Helicobacter pylori was removed, the risk of developing the disease still rose in line with the dose and duration of PPI treatment.
    They compared the use of PPI against another drug which limits acid production known as H2 blockers in 63,397 adults. The participants selected had been treated with triple therapy, which combines PPI and antibiotics to kill off the H pylori bacteria over a week, between 2003 and 2012....

    H2 blocker:
    • Famotidine (Pepcid AC, Pepcid Oral)
    • Cimetidine (Tagamet, Tagamet HB)
    • Ranitidine (Zantac, Zantac 75, Zantac Efferdose, Zantac injection, and Zantac Syrup)
    • Nizatidine Capsules (Axid AR, Axid Capsules, Nizatidine Capsules)
     
    CFS_for_19_years, sb4, Diwi9 and 2 others like this.
  2. Learner1

    Learner1 Professional Patient

    Messages:
    1,081
    Likes:
    1,732
    Pacific Northwest
    Yup. Good point.:thumbsup:
     
  3. Diwi9

    Diwi9 Senior Member

    Messages:
    507
    Likes:
    1,862
    USA
    @Ecoclimber - Thank you for posting this. I have a friend who has been on PPI's for a long time and shared the article with them.
     
  4. Stretched

    Stretched Senior Member

    Messages:
    189
    Likes:
    178
    U.S., Southeast
    How about Protonix, which is a PPI but different chemistry than the others? It’s used by heart disease people who are taking otherwise conflicting medications, eg me.

    Is it the drug or acid reflux which the study says is the cause?
     
    Last edited: Nov 4, 2017
  5. perchance dreamer

    perchance dreamer Senior Member

    Messages:
    1,293
    Likes:
    1,844
    I used to have really bad GERD, but got rid of it with digestive enzymes, probiotics, and D-Limone. The D-Limone is what helped me the most. It helps repair the lining of the esophagus.
     
    Timaca, mermaid and Learner1 like this.
  6. sb4

    sb4 Senior Member

    Messages:
    414
    Likes:
    468
    United Kingdom
    If GERD is caused by low acidity yet the doc assumes its due to high acidity, then you are decreasing low levels even further. Stomach is in the wrong environment = cancer.
     
    anni66 and Learner1 like this.
  7. mermaid

    mermaid Senior Member

    Messages:
    596
    Likes:
    1,065
    Cornwall, UK
    That is interesting. I will give this a try - I seem to have tried everything else! I think most of my problems are down to a small hiatus hernia, but if I keep to a restricted diet then it does improve (being weak willed I cannot always manage that!)
     
  8. Stretched

    Stretched Senior Member

    Messages:
    189
    Likes:
    178
    U.S., Southeast
    Thanks. It seems I've seen this as a supplement vs rx?
     
  9. perchance dreamer

    perchance dreamer Senior Member

    Messages:
    1,293
    Likes:
    1,844
    Yes, D-Limone is a supplement. I buy Jarrow D-Limone from Amazon.
     
    mermaid likes this.
  10. Ecoclimber

    Ecoclimber Senior Member

    Messages:
    988
    Likes:
    2,424
    GERD is usually caused by by the poor closure of the lower esophageal sphincter (the junction between the stomach and the esophagus) which causes acid to flow in the lower esophagus. The failure sphincter muscle to close properly allows the flow of the acid reflux into esophagus which can cause esophageal cancer. Barrett's esophagus may be caused by GERD. Over time, stomach acid in the esophagus can cause changes in the cells that increase risk for adenocarcinoma. Sometimes burning or pain can be mistaken for cardiac issues as you can see in the image. These condition increases in an older populations age range 55+


    [​IMG]



    PPI
    omeprazole (Prilosec, Prilosec OTC)
    aspirin and omeprazole (Yosprala)
    lansoprazole (Prevacid, Prevacid IV, Prevacid 24-Hour)
    dexlansoprazole (Dexilent, Dexilent Solutab)
    rabeprazole (Aciphex, Aciphex Sprinkle)
    pantoprazole (Protonix)
    esomeprazole (Nexium, Nexium IV, Nexium 24 HR)
    esomeprazole magnesium/naproxen (Vimovo)
    omeprazole/sodium bicarbonate (Zegerid, Zegerid OTC)

    Daily use of PPIs was associated with a risk of developing the illness that was more than four times higher (4.55) than those who used it weekly. Similarly, when the drug was used for more than a year, the risk of developing stomach cancer rose five-fold, and as high as eight-fold after three or more years, the findings showed.

    There are anecdotal reports on here that PwME have benefited by taken Ranitidine ( Zantac) that helped their ME/CFS symptoms
     
    Last edited: Nov 4, 2017
    sb4 and Stretched like this.
  11. Stretched

    Stretched Senior Member

    Messages:
    189
    Likes:
    178
    U.S., Southeast
    Thanks for info, but caution: my cardio put me on Protonix vs other ‘-secs’ which is a PPI but different chemistry than the others? It’s used by heart disease people who are taking otherwise conflicting medications. I have CAD and 2 stents in heart.
     
  12. alex3619

    alex3619 Senior Member

    Messages:
    12,480
    Likes:
    35,011
    Logan, Queensland, Australia
    I see relative risk but what is the absolute risk from PPIs. Distinguishing between the two types of risk gives perspective.
     
  13. anni66

    anni66 mum to ME daughter

    Messages:
    208
    Likes:
    815
    scotland
    I'm assuming that the sphincter valve is PH regulated. The "top" gut is supposed to be a highly acidic environment to enable minerals and proteins to be processed.The lower gut is the fermenting one. When the acidity is wrong (ie not enough) the valve will open to adjust - so this is contraindicative? Acid reflux is due to not enough acid - probably due to gut dysbiosis?
     
  14. alex3619

    alex3619 Senior Member

    Messages:
    12,480
    Likes:
    35,011
    Logan, Queensland, Australia
    https://www.cancer.org/cancer/stomach-cancer/about/key-statistics.html

    If this data and the study are right, the risk goes from under one percent to nearly five percent for long term PPI use. That is major in my opinion. The mitigating factor is that this is going to be more prevalent in older patients. Its still not fun for those older patients.
     

See more popular forum discussions.

Share This Page