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Acid Inhibition Associated with B12 Deficiency

Discussion in 'Other Health News and Research' started by MeSci, Dec 12, 2013.

  1. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    Cornwall, UK
    I thought this item from Physicians' First Watch would interest people with ME, as many of us seem to have B12 deficiency and some have taken/are taking proton pump inhibitors (not sure re histamine-2 receptor antagonists).

    aimossy likes this.
  2. Marco

    Marco Old blackguard

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    Near Cognac, France
    Nice to know thanks.

    I was taking Tagamet for about 3 years in the early 90's.
  3. Helen

    Helen Senior Member

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    Thanks MeSci.
    Also people with hypothyroidism, who are not properly treated ( too often they are not .See www.stopthethyroidmadness.com) and they may because of that have too little stomach acid for a good B12 uptake.
    Then we now know that all but a few here on PR have polymorphisms that also (might) impair the B12 metabolism (MTHFR+MTR/MTRR).

    Edit (see MeSci) : I meant "all that have been gene tested" as we canĀ“t know about others. Just a guess if they feel much better on B12 and/or folate ...as so many do.
    Last edited: Dec 13, 2013
  4. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    I wonder whether the majority here know whether or not they have these polymorphisms. I don't know whether I have. I had some genetic tests years ago but can't remember where I put the results! So I don't know whether they did those ones. Must try to find them...
  5. Helen

    Helen Senior Member

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    You are right. I should have written "all that have been gene tested". That is what I thought. Hope you will find your tests! MTHFR is the most explored of all , I was told, so hopefully you will find at least this SNP.
    MeSci likes this.
  6. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    I have found it! Now I have to do some reading on here about what relevance the polymorphisms have for ME. The blurb with my results already points to some relevant issues.

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