@MissCB : In the past, I tried many things for POTS, 2 of them happened to be PP ingredients...thiamine and ALC. I didn't experience any significant changes but so many things have been tried and sometimes overlapping with other supps or meds so its difficult to say how the overall affect truly was of those supplements for dysautonomia. Certainly didn't help with the constipation though. I did recently try the Alpha GPC but will admit I didn't stick with it very long so I can't comment on any negative effects such as your tingling brain feeling. I stopped taking within a week b/c I was nervous of messing up my newly found 'success' of daily dosing with Mirulax and 1000 mgVit C powder. But when I had a few sudden cognitive impairment challenges last week (severe), the memory of my hell with POTS scared me so bad that I immediately thought of trying PP since Dr. Driscoll promotes it at her POTS Care clinic. It will arrive this weekend and I will try it right away. Hopefully no negative issues arise My stomach motility (gastroparesis) has been better since following the FODMAP diet (loosely) and starting a PPI for severe GERD but only Mirulax and at least 100mg Vit C /day help with the colonic inertia..constipation.