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ACAT SHMT CBS

Discussion in 'Genetic Testing and SNPs' started by mayrooni, Sep 5, 2013.

  1. mayrooni

    mayrooni

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    I have heteros for all of them...which do I treat first? I am finding conflicting information on this...and is there a basic protocol? New to this and just trying to get started.
  2. Valentijn

    Valentijn Activity Level: 3

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    You can ignore the ACAT ... the ACAT SNPs shown on the Yasko profile are irrelevant to the functioning of the gene. SHMT shouldn't be a problem unless you also have MTHFR C677T.
  3. mayrooni

    mayrooni

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    i am homo 1298...so i can start with cbs? i have found conflicting info on that...some say yes to start there, some say its does not affect...any insight on that? i saw on yaskos simplified map that there are 7 supplements for it...would one take all of them? or just the ones that seem to be associated with the issue?
  4. mayrooni

    mayrooni

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    and my kids have c677t and shmt...any info on treating it then?
  5. mayrooni

    mayrooni

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    i should add they are compound hetero
  6. Valentijn

    Valentijn Activity Level: 3

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    CBS C699T doesn't require treating, except maybe some B6 if it's -/-.
  7. Valentijn

    Valentijn Activity Level: 3

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    Compound hetero for what? MTHFR C677T and A1298C? If so, their methylfolate production is at 30% of normal if each + allele came from a different parent. Otherwise it's at 65% of normal.

    SHMT added to MTHFR C677T would mean even more problems creating methylfolate. Hence more methylfolate and/or folinic acid (not folic acid) might be helpful.
    Critterina likes this.

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