I read about MTHFR and a lot of the symptoms are things that I have had. I have been diagnosed with CFS and bipolar disorder but they both went away when I stopped eating gluten, soy, yeast and dairy 10 years ago. Actually the bipolar went away immediately and the CFS went away 2 years later. About 2 years ago my IBS went on vacation when I did some work with probiotics (and other stuff). It came back last month when I went on a whole30 diet. Anyway when I heard about the MTHFR gene mutation, all of my "syndromes" had a common cause. So I am going to be doing a genetic test. I thought while I was waiting for the response, I would do a test with a methylated b-complex. I have been taking 1 daily: Vitamin B2 (Riboflavin-5-phosphate sodium) 2.5 mg Vitamin B3 (Niacin-from 129 mg Inositol Hexanicotinate per capsule) 118 mg 197% Vitamin B6 (Pyridoxal-5-phosphate) 33 mg 550% Folic Acid (calcium L-5-methyltretrahydrofolate) 333 mcg 83% Vitamin B12 (Methylcobalamin) 333 mcg 5556% Biotin 167 mcg 56% Vitamin B5 (Pantethine, Calcium d-Pantothenate) 100 mg 333% Vitamin B1 (Benfotiamine) 33 mg Choline bitartrate 200 mg Inositol (from Inositol, Inositol Hexanicotinate) 131 mg* I thought if I indeed was insufficient in methylfolate or methylcobalamin then I would likely have some reaction. But nothing. Any ideas? Am I dreaming about a MTHFR connection. I have always had poor adsorption of vitamins, I injected B12 (cyanocobalamin) whenever I had symptoms to make them go away but my serum b12 has been high. I take 10 D3 in order to avoid bone pain and other vitamin d deficiency symptoms and I still struggle in the February/March timeframe. So whenever I have to take a vitamin I seem to do better avoiding my stomach. Could it be my poor absorption is hiding the methylation process? Thanks for your help.