The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Aberrant Resting-State Functional Connectivity in the Salience Network of Adolescent CFS

Discussion in 'Latest ME/CFS Research' started by mango, Jul 15, 2016.

  1. mango

    mango Senior Member

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    Aberrant Resting-State Functional Connectivity in the Salience Network of Adolescent Chronic Fatigue Syndrome.

    Wortinger LA
    1,2, Endestad T2, Melinder AM3, Øie MG2,4, Sevenius A2, Bruun Wyller V1.

    Author information
    1 Department of Pediatrics, Akershus University Hospital, Nordbyhagen, Norway.
    2 Department of Psychology, University of Oslo, Oslo, Norway.
    3 Cognitive Developmental Research Unit, Department of Psychology, University of Oslo, Oslo, Norway.
    4 Research Department, Innlandet Hospital Trust, Lillehammer, Norway.

    PLoS One. 2016 Jul 14;11(7):e0159351. doi: 10.1371/journal.pone.0159351.

    Abstract
    Neural network investigations are currently absent in adolescent chronic fatigue syndrome (CFS). In this study, we examine whether the core intrinsic connectivity networks (ICNs) are altered in adolescent CFS patients. Eighteen adolescent patients with CFS and 18 aged matched healthy adolescent control subjects underwent resting-state functional magnetic resonance imaging (rfMRI). Data was analyzed using dual-regression independent components analysis, which is a data-driven approach for the identification of independent brain networks. Intrinsic connectivity was evaluated in the default mode network (DMN), salience network (SN), and central executive network (CEN). Associations between network characteristics and symptoms of CFS were also explored. Adolescent CFS patients displayed a significant decrease in SN functional connectivity to the right posterior insula compared to healthy comparison participants, which was related to fatigue symptoms. Additionally, there was an association between pain intensity and SN functional connectivity to the left middle insula and caudate that differed between adolescent patients and healthy comparison participants. Our findings of insula dysfunction and its association with fatigue severity and pain intensity in adolescent CFS demonstrate an aberration of the salience network which might play a role in CFS pathophysiology.

    DOI: 10.1371/journal.pone.0159351

    http://www.ncbi.nlm.nih.gov/pubmed/27414048
     
    JaimeS, Valentijn, merylg and 3 others like this.
  2. Denise

    Denise Senior Member

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    I haven't read this yet (am wayyyy behind), so I don't know when the results were analyzed, but I wonder how this study holds up given the software bugs in fMRIs that were updated in May 2015.
     
    Valentijn and adreno like this.
  3. Justin30

    Justin30 Senior Member

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    Why is SPECT and PET scans so underused in studies is it that they could actually show the damage that is done by this disease?

    Makes me scratch my head these 2 methods are proven.
     
  4. Valentijn

    Valentijn Senior Member

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    It's basically just psychobabblers playing with MRIs.

    They focused heavily on fatigue, and rejected Fukuda as being too stringent and unproven, in favor of NICE (despite being Norwegian research), which they defined as 3 months of unexplained fatigue. Their basic hypothesis and conclusion boil down to "sustained arousal" in response to "stress", and the brain's misinterpretations of (normal? imaginary?) sensations.

    Full text at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159351
     
  5. Cheshire

    Cheshire Senior Member

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    Whatever Willer does, his conclusion is always "sustained arousal", even when medication supposed to prevent stress responses makes people worst...
     

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