I have had this shot, which I explained a while back (3 years ago) for food allergies. It's extremely expensive. Like $300 a month expensive. It helps tremendously with my food allergies; for example, I have an awful rash and tomorrow when I get the shot, the rash with go away. Also, the feeling of absolute awfulness won't be so so bad. I have had to take a break from it for a few months. In that time, I have noticed a lot of things. For one, my food allergies are the most prominent symptom. The worst symptom that is really kind of ruining my life. But also, that the total histamine cascade is causing pain. Lots of pain. Also, I have noticed that I am not as empathetic on the shot. I don't have empathy on it. It's like I am missing a fundamental emotion. I am more black and white on it. So, it's helping my food allergies, but it's also ruining other aspects of my personality. This is not the first time I have noticed this with a treatment. Where something will help you, but cause horrible symptoms in other ways. Years ago I was on a vitamin protocol that was insane. Like 20 supplement pills a day. It helped with endometriosis and energy. I was able to go to college and work. However, it made me nuts at times. Lots of tyrosine and niacin along with NADH. I felt unbalanced, but it rid me of absolute to die for pain with endometriosis. So, you feel better in some ways and worse in others. It's a crap shoot. Does anyone else have this with treatments? I honestly feel like I am held together by tape. Like, yes, this shot tomorrow will put me back together in some ways, but will do damage in other ways. Why can't things just work all the way? What is it like for that to happen? Also, to have something work in the beginning and then just not work. That's another fabulous thing to happen to us CFS folks. Flowers for Algernon...that's how it is for us.