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A report about anti-glycation supps Carnosine Beta-Alanine (=methylation?)

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Gondwanaland, Mar 31, 2017.

  1. Asklipia

    Asklipia Senior Member

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  2. Gondwanaland

    Gondwanaland Senior Member

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    @Asklipia I am not sure if I understand your concern. Carcinine escapes carnosinase action beacuse it is a modified carnosine.

    Just like imidazoles, Carcinine blocks DAO from what I have read so far.

    Thanks for adding this fascinting article, I am trying to digest it :thumbsup:
    It seems to be nothing short of miraculous indeed :wide-eyed:
     
    Last edited: May 27, 2017
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  3. Gondwanaland

    Gondwanaland Senior Member

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    The question is, is a certain amount of glycation needed fro healthy collagen formation?
    Adding literature:
     
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  4. Asklipia

    Asklipia Senior Member

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    First thank you so much for your bringing so many interesting points and sharing them here. I am sure this will be immensely useful to many. It will take some time before I understand all this.

    As to my concern about carnosinases, it is just that in so many ways, what is happening to us is like a carnosinase not a carnosine deficiency, since we can overcome it with carcinine.
    I say this because nothing in our diet, as far as I know, has induced a carnosine deficiency. We eat meat of all kinds, and generous helpings. Always have, and if we don't for more than a week we are sick.
    I suppose we could have a condition which does not allow for absorption of carnosine in our food. I though maybe a kind of gut disorder?
    But we seem to be able to get strong fast results with a carnosinase resistant carnosine (carcinine).

    This is why my thoughts go towards a carnosinase problem. What if we were full of carnosinase? Could it be because of the incredible increase in citrate preservatives everywhere around? In Asia, they are replacing boric acid as a preservative. Now boric acid is a great help to the prostitution industry. Let's see what happens in Bangkok when boric acid has disappeared from restaurants. But we never eat anything preserved, or not preserved by ourselves and this has been true for at least 20 years.

    Or could this carnosinase upsurge (supposing it is true, of course, that we harbour too much carnosinase) be a result of the presence or absence of some bacteria? Which would explain the bacterial element in obesity?

    You see, if we can fix this for ourselves, I would be forever on the lookout to avoid a relapse. I don't just want my health back, I want to know why it suddenly crumbled away.
    :hug:
     
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  5. Gondwanaland

    Gondwanaland Senior Member

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    A carnosinase overactivity destroying carnosine?
    Carnosine is not ingested, it is made by the body by bonding B-Alanine from meats + histidine. Vegetarians risk to have a deficiency in Carnosine.
    I noticed that when I was taking carcinine, in addition to be tolerating all kinds of foods in any amount (still avoided gluten though), I especially needed to eat lots of high histamine-high oxalate foods, they seemed especially healing. Then in my relapse after I stopped taking carcinine, the phenols, tryptophan and sulfites were especially damaging. B1, Biotin and lysine supplements had an intriguing positive effect. I think because Biotin has a crucial role in protein metabolism (esp. Lysine and BCAAs can adversely interfere in the Tryptophan metabolism under Biotin deficiency) and apparently the biotinidase enzyme (needed to free biotin from food) can be easily inhibited. So in your case it could be a cascade effect... Try to look into it perhaps... B5 competes with Biotin for absortion/transport in the body. B2 and B6 are supportive to Biotin metabolism. It is a snowball :ill:
    I read that carnosinase is activated by manganese.
    Perhaps... But in my experience a small amount of citrus fruit is beneficial. I don't know about food preservatives since just like you I pretty much reduced the intake of processed foods drastically since 2013 (it is close to zero now).

    Me too.

    You made some interesting questioning there, Asklipia :hug:
     
    Last edited: May 28, 2017
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  6. Gondwanaland

    Gondwanaland Senior Member

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    BTW Carnosine synthesis is stimulated by exercise.
     
  7. Asklipia

    Asklipia Senior Member

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    :thumbsup:
     
  8. Asklipia

    Asklipia Senior Member

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    More on the Japanese front :
    The Effect of Chicken Extract on Mood, Cognition and Heart Rate Variability
    Hayley Young, David Benton and Neil Carter


    EOC resulted in feeling less anxious, depressed and confused and more agreeable and clearheaded. :):balloons::)
     
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  9. Gondwanaland

    Gondwanaland Senior Member

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    Attached Files:

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  10. Asklipia

    Asklipia Senior Member

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    @Gondwanaland I found this article
    Carnosine and carnosine-related antioxidants: a review.
    extremely interesting, but no time to discuss, leaving for an internet-free week!
    Enjoy! :hug:
     
    Last edited: Jun 8, 2017
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  11. Gondwanaland

    Gondwanaland Senior Member

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    Thank you so much for the paper, I will read it with interest!

    Happy holidays :hug:

     

    Attached Files:

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  12. Gondwanaland

    Gondwanaland Senior Member

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    For those with low iron, and tending to alkalosis, it might not be a safe supplement
    @picante @Lolinda
     
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  13. picante

    picante Senior Member

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    Helena, MT USA
    This language is so unclear! Does "complex" as a verb just mean to form complexes with? So the ions get attached to something? Does "regulation" mean "lowering"? Or something else?
     
  14. Gondwanaland

    Gondwanaland Senior Member

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    Ha! Good questions o_O

    In my personal interpretation:

    complex = bind
    regulation = depletion
     
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  15. Gondwanaland

    Gondwanaland Senior Member

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    From what I read, I think it works a bit like ALA (I never took ALA).
     
  16. NotThisGuy

    NotThisGuy Senior Member

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    Hi,
    about carnosine and heavy metals:
    A Dr. in germany (specialist for Lyme and MCAS/Mastocytosis) performed tests regarding carnosine and heavy metals.
    His experience is that carnosine chelated aluminium but other heavy metals were unaffected.

    @Gondwanaland Do you know if u have a heavy metal toxcity?
     
  17. Gondwanaland

    Gondwanaland Senior Member

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    I have sick building, lead and mercury environmental exposure + 5 amalgam dental fillings.

    As I posted in this thread a couple of weeks ago, at some point I felt my amalgams were actively leaching, and so did my husband in the same days I did (he took 1 dose of B-Alanine).

    The hair test I had back in 2013 showed Aluminum in the high red, and a few others in the low green.
     
  18. Asklipia

    Asklipia Senior Member

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    DH and I are still on 4 mg carcinine per day. We find this is more than enough to give us both incredibily soft skin!!!!!!!!!!! A bit like the kind of soft you get from vitamin K in large amounts.
    :balloons::thumbsup::thumbsup::balloons:
     
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  19. Lolinda

    Lolinda after meals, I need to lay in bed for hours

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  20. CFS_for_19_years

    CFS_for_19_years Hoarder of biscuits

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    USA
    http://www.lifeextension.com/magazine/2011/1/Carnosine-Exceeding-Scientific-Expectations/Page-01
    https://www.herballoveshop.com/product.asp?PID=22101
    Carnosine is best taken on an empty stomach.
     
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