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A report about anti-glycation supps Carnosine Beta-Alanine (=methylation?)

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Gondwanaland, Mar 31, 2017.

  1. Gondwanaland

    Gondwanaland Senior Member

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    Last edited: Apr 14, 2017
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  2. Gondwanaland

    Gondwanaland Senior Member

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  3. Tunguska

    Tunguska Senior Member

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    That's interesting to me, because I'm "forced" to consume more citrate than I would like, in the form of orance juice + baking soda, and it's looking as though citrate is really not very good. (the juice has a lot of hesperidin though)
     
  4. Gondwanaland

    Gondwanaland Senior Member

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    Interestingly lemon juice is promoted as a healthy beverage for daibetics since acidic stuff improve insulin sensitivity.

    For a long time I had been drinking a squeezed lemon in a glass of water before breakfast mainly to increase hydrochloric acid and improve digestion of breakfast, but since it can additionally have anti-estrogenic effects (AND I may have awaken an old ulcer), I am giving up on it.

    Hesperidin is highly anti-estrogenic.
    why is that so if I may ask?
     
  5. Tunguska

    Tunguska Senior Member

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    Because of diet limitations. It's extreme by health nut standards but I rely on potassium-rich juices to get carbs and avoid most fibre except the select forms I tolerate, and orance juice although clearly flawed is one of my better options (as long as it's with baking soda). I require this to avoid gut disturbance and this appears to be more significant to my health than other considerations.

    I'm not worried about anti-estrogenic effects and I get no apparent side effects on joints from hesperidin or anti-estrogen things. But I don't seek out hesperidin and might avoid it if I could just because it's a flavonoid with two-faced effects on mTor... but on the other hand I have a theory that it actually helps joints because it's an MMP inhibitor, and it may even increase BDNF in the brain. I think it's the only flavonoid I get in large quantities, and you could definitely do worse, unless the anti-estrogen is a serious issue for you.

    Citrate on the other hand, appears to be a clear negative, and I have to be getting lots.
     
  6. Gondwanaland

    Gondwanaland Senior Member

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    Is that a stomach ulcer? I am dealing with an ulcer right now... Will have an endoscopy next week, but had been diagnosed with a gastric ulcer back in 2010. Took several doses of pantoprazole until 2013 when I went gluten free and never had GERD or any stomach pain anymore and abandonned the PPIs for good.

    So last month I was taking digestive enzymes (DPP-IV + Bromelain + Pepsin + Pancreatin) + Carcinine (which seemed especially acidifying), took Rutin + Bromelain + Trypsin a couple of times (it was miraculous for PEM and joint pain), then drank wine on one occasion and the pain I usually feel as a pressure on my back revealed itself as a probable ulcer, plus pain in 2 different points at the front of my stomach. B vitamins aggravate it (esp. B6-HCl).

    Counter-intuitively, I am finding that a propolis alcoholic solution taken 30-60min before meals seems to protect the stomach wound in the back, but doesn't seem to help the frontal ones.

    The most pressing issue has been the need to excrete uric acid which was impaired by low estrogen. After starting HRT this and several other issues resolved. Then carcinine tanked my levels even with replacement (estradiol is a phenol and it sped up its breakdown together with calcitriol and thyroid hormones).

    Despite all that, I intend to take the carcinine at a lower dose perhaps 2x weekly, because I do need a hand with phenol and sulfite breakdown. It relieves fatigue, PEM and food intolerances, it seems to give me a normal appetite and I can reach and go beyond 2,000 calories daily.

    At some point I hope to be able to take K2-MK4 (not without a little calcium and lysine).

    Having said all that, I wonder if the fact that my blood type is O would be worsening the high acidity issues.

    @Lolinda
     
    Last edited: Apr 15, 2017
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  7. Gondwanaland

    Gondwanaland Senior Member

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    BTW estrogen receptors seem to be connected with protein digestion, since I took DPP-IV to help me break down the proline bonds and as a side effect I felt activation of estrogen receptors.

    Also the bromelain seems to quickly produce purines, and I am under the impression that the anti-glycation supp increases pyrimidines and balances that.
     
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  8. Asklipia

    Asklipia Senior Member

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    @Gondwanaland Sorry about your ulcer.
    Two people I know have successfully resolved all stomach ulcer problems.
    My husband, by taking a homeopathic remedy :
    https://www.soin-et-nature.com/fr/w...mplexe-c-228-trituration-30g-homeopathie.html
    He takes a pinch when he feels his stomach, and the felling disappears. He has not used it in the last ten years, I suppose he is OK now.
    A good friend takes this Brazilian plant. Chew a couple of leaves a few times a day, then spit out:
    Same thing, he is now cured no symptoms in the last ten years.
    Bálsamo-verde
    Nome Científico: Sedum dendroideum praealtum
    Thank you for all this information on carnosine! I am going to try. Should get my carcinine around 1st May and will report in detail.
     
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  9. Gondwanaland

    Gondwanaland Senior Member

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    Thank you very much, I will look into the homeopathy and this plant! never heard of it...
    I am considering to switch to carnosine!
    I recommend you to read thoroughly the 2 reviews I posted above.
     
    Last edited: Apr 15, 2017
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  10. Tunguska

    Tunguska Senior Member

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    No, just general CFS/ME/possiblyother symptoms that are unpredictably worse depending on fiber and foods. I very clearly have gut problems but I already gave up trying to fix them, this simply minimizes the blowback on the body and it's the only thing that fairly consistently works.

    Afraid I can't give you much input on the rest of that, so best wishes.
     
  11. Gondwanaland

    Gondwanaland Senior Member

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    I know what you mean. after a rollercoaster with probiotics I finally found something that worked (B. infantis + B. longum), but unfortunately it is ruined now.

    Regarding my ulcer, it seems that stopping the carcinine cold turkey might have aggravated it:

    It seems to be a Mexican plant, and despite being popular in Brazil, impossible to buy online. The active molecule is kaempferol, and I do have Maytenus at home which is rich in it, with the added benefit of raising estrogen. Hoping not to get a migraine from it...
     
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  12. Gondwanaland

    Gondwanaland Senior Member

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    @Lolinda
     
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  13. Gondwanaland

    Gondwanaland Senior Member

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    Hipkiss 2009 p. 119
    So carcinine may not help with stroke
     
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  14. Gondwanaland

    Gondwanaland Senior Member

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    I can't emphasize this enough:

    Hipkiss 2009
    So it can increase the need for calcium like K2-MK4 does.
     
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  15. Gondwanaland

    Gondwanaland Senior Member

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    I am under the impression that citrate stimulates carnosine turnover, so not a bad thing after all.
     
  16. Asklipia

    Asklipia Senior Member

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    I have received my carcinine and taken 100 mg per day for the last three days. Immediate boost in energy, a couple of detox pimples straightaway. Consistent with what you have reported in the first post of this thread.
    This did not occur with normal carnosine 500 mg.
    So there must be a special effect. How safe? I do not recommend anything!!!!!! Just reporting.
    Be well! :hug:
    EDIT : I just realized that the 100 mg I have been taking of Glycoxil contain just 10 mg carcinine. So effecyively I have been taking 10 mg carcinine per day.
     
    Last edited: May 6, 2017
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  17. Asklipia

    Asklipia Senior Member

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    Last edited: May 6, 2017
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  18. Gondwanaland

    Gondwanaland Senior Member

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    Should you discontinue it, I recommend a slow tapering down, not cold turkey like I did :bang-head: because it optimizes sulfite oxidase (my personal conclusion), and if you stop abruptly you will become extremely sulfite intolerant.

    If you need to read about sulfites, I have a long reference list with published studies.
     
  19. Asklipia

    Asklipia Senior Member

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    Thank you for the advice! How long did it take you to get over the sulfite pxydase problem? Did you do anything special?

    I noticed today that I refused a glass of wine with my lunch. I had absolutely no desire for it.
     
    Last edited: May 9, 2017
  20. Gondwanaland

    Gondwanaland Senior Member

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    I observed some new food intolerances for about one month when only butter+honey helped allergies (rhinitis), and about a week ago I reintroduced my probiotics (which haven't been helping) Milk Thistle and silica (helped a little), and microdosing B2, B6 and lisine (helped a lot).
    How odd, in my imagination I would drink as much wine as I wished if I took carcinine steadily with the proper companion nutrients... Perhaps there is some nutrient conflict with your high dose B1 (wild guessing).

    BTW I noticed increased blue light intolerance AFTER DISCONTINUING IT (esp. LED) and 0.5mg B2 at bedtime has been a life/sleep saver.
     
    Last edited: May 5, 2017
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