This is about all the various protocols. First, if you are going to give any specific protocol a try, give it a real try. There are reason for this. First of all as many have found, brands are not all equal, whether of vitamins or other nutrients or medications. Second, exact combinations can make as much difference as specific brands or varieties. There can be alternate items based on response. One of the biggest examples I know of, and pone that totally took me by surprise, was this whole ALCAR or L-carnitine fumarate or mix of forms item To me it indicates a very fundamental difference that one form can be so completely effective and another completely ineffective and makes no difference for some people. The point is, if a person has no effects from X1, then they need to try X2 or X3. This was part of the complications and tediousness that caused Rich to attempt a "simplified" plan without all the complications. Another reason for following a specific protocol is that it puts you onto the "map". If for instance a person is taking folic acid and asks "why am I having these folate deficiencies?" that has possible contradictory answers. For instance if the folic acid is working it could be donut hole folate insufficiency or if could be blocking the methylfolate and that is a different answer. The same is true with HyCbl. Somebody gets acne that doesn't go way after an injection. Is it because the HyCbl isn't effective and causes the tissue malformation or because it is effective and causes donut hole folate deficiency or maybe because of methyltrap caused by glutathione or NAC? Without a "standardized" base that puts one on the therapeutic map for that specific protocol. Of there isn't a "therapeutic map" of effects then everybody is guessing. At best it is an approximation, an estimate when on the map because of so many variations. However, at least some protocols make predictions about transitory effects and what they mean to adjusting the protocol. Of course if not enough people have clearly healed on a protocol it is impossible to have a therapeutic map, at least as far as people have healed. So an example is having low folate and low potassium several days after starting methylation supplements as a prediction with a possible fix to try. If it is blockage by folic acid then it often takes far more methylfolate to overcome the folic acid and get rid of the symptoms. There are far more pathways than those mapped so far. Good health.