I watched the following presentation today, which I found facsinating, regarding many aspects of ME/CFS research. The link to the presentation is: http://www.masscfids.org/videofiles/Komaroff/Komaroff.html It takes a while for it to open up, but it does at the end... :Retro smile: Now, my question is about something that he talked about and can be view instantly if you'll press the row that says: "34 - XMRV (Retrovirus) inc CFS (2)", down on the left side. There he shows a table that shows how many people were tested for XMRV by each of the 4 methods by the WPI, and every time, how many of them were positive for XMRV. Besides the fact that it is the first time, I think, that I see that WPI also tested some of the healthy controls (although not all of them, not even close) by these methods (and all were found negative for XMRV), the thing that interests me is the following: By PCR, 67% of the tested subjects were found positive for XMRV. By viral protein expression, 63% of the tested subjects were found positive for XMRV. by infectious virus in the plasma, 83% of the tested subjects were found positive for XMRV. And, by antibodies to virus in serum, 50% of the tested subjects were found positive for XMRV. Now, at least for the unaware viewer, that would seem as if the serology test is the least accurate one - and that is in oppose to the feeling I previously got that it would be the most accurate one. However, I guess there very well might be other explanations for that. Perhaps the 18 subjects that were tested for antibodies had the biggest group of people that were negative for XMRV by all other tests? Or, perhaps WPI is actually saying that the antibodies test is not the most accurate one, but it would give more accurate results when it is combined with the culture test - as oppose to the results we would get from culture test alone? Or, could it be that the antibodies test that WPI did for this study, which was published almost 8 months ago (and the tests were probably done before that) is, actually, the least accurate method - But the method that VIP Dx developed for antibodies test would be the most accurate? If someone has some insights about that, I'd be glad if they could be shared.