The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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A potential biomarker for fatigue: oxidative stress and anti-oxidative activity

Discussion in 'Latest ME/CFS Research' started by JaimeS, May 21, 2016.

  1. JaimeS

    JaimeS Senior Member

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    A potential biomarker for fatigue: oxidative stress and anti-oxidative activity

    Look, guys, it's Fukuda!


    Highlights

    • Fatigue is a frequent symptom in both healthy individuals and patients, therefore, biomarkers indicating several differential levels of fatigue would be needed for evaluating fatigue and its improvement.

    • Following the hard work term, the mean values of oxidative stress increased; however, anti-oxidative activity did not decrease, except only one case.

    • Measured of oxidative stress (d-ROMS) and anti-oxidative activity (BAP) might be useful for discriminating acute, sub-acute, and resting fatigue in healthy people from patients with CFS, or for evaluating fatigue levels in healthy people.

    Abstract
    We sought to determine whether oxidative stress and anti-oxidative activity could act as biomarkers that discriminate patients with chronic fatigue syndrome (CFS) from healthy volunteers at acute and sub-acute fatigue and resting conditions. We calculated the oxidative stress index (OSI) from reactive oxygen metabolites-derived compounds (d-ROMs) and the biological antioxidant potential (BAP). We determined changes in d-ROMs, BAP, and OSI in acute and sub-acute fatigue in two healthy groups, and compared their values at rest between patients with CFS (diagnosed by Fukuda 1994 criteria) and another group of healthy controls. Following acute fatigue in healthy controls, d-ROMs and OSI increased, and BAP decreased. Although d-ROMs and OSI were significantly higher after sub-acute fatigue, BAP did not decrease. Resting condition yielded higher d-ROMs, higher OSI, and lower BAP in patients with CFS than in healthy volunteers, but lower d-ROMs and OSI when compared with sub-acute controls. BAP values did not significantly differ between patients with CFS and controls in the sub-acute condition. However, values were significantly higher than in the resting condition for controls. Thus, measured of oxidative stress (d-ROMS) and anti-oxidative activity (BAP) might be useful for discriminating acute, sub-acute, and resting fatigue in healthy people from patients with CFS, or for evaluating fatigue levels in healthy people.

    Abbreviations

    • CFS, Chronic fatigue syndrome;
    • d-ROMs, Reactive oxygen metabolites-derived compounds;
    • BAP, biological antioxidant potential;
    • OSI, Oxidative stress index;
    • VAS, Visual analogue scale;
    • HVs, Healthy volunteers;
    • IO&NS, oxidative and nitrosative stress

    Keywords
    • fatigue;
    • oxidative stress;
    • anti-oxidative activity

    Corresponding author at: University of Kansai Welfare Sciences, Kashiwara, Osaka 582-0026, Japan.

    © 2016 Published by Elsevier B.V.

    _______________________________________________________

    Hmm, actually this seems like an attempt to distinguish 'ordinary fatigue' from CFS. Link to abstract here.


    -J
     
    Last edited: May 21, 2016
  2. Denise

    Denise Senior Member

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    NOTE - The Fukuda associated with the cfs definition is Keiji Fukuda (not Sanae) who is now with WHO
    http://www.who.int/dg/adg/fukuda/en/
    and
    https://en.wikipedia.org/wiki/Keiji_Fukuda
     
    L'engle, sarah darwins, Mij and 5 others like this.
  3. JaimeS

    JaimeS Senior Member

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    You're right, Denise! It's another Fukuda in CFS!
     
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  4. Denise

    Denise Senior Member

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    Several of these authors also worked on:

    J Nucl Med. 2014 Jun;55(6):945-50. doi: 10.2967/jnumed.113.131045. Epub 2014 Mar 24.
    Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study.
    http://www.ncbi.nlm.nih.gov/pubmed/24665088
     
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  5. Snow Leopard

    Snow Leopard Hibernating

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    They used Fukuda critria, report that 83/121 "showed post-malaise fatigue".

    If you were confused by what they meant by "acute and sub-acute":

     
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  6. JaimeS

    JaimeS Senior Member

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    Wow. That's... a large gap between the two categories of cognitive ability!
     
    L'engle likes this.

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