Abstract: There is no accepted science to relate herpesviruses (EpsteinBarr virus [EBV],human cytomegalovirus [HCMV], and human herpesvirus 6 [HHV6]) as causes of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). ME/CFS patients have elevated serum immunoglobulin (Ig)G serum antibody titers to EBV, HCMV, and HHV6, but there is no herpesvirus DNA-emia, herpesvirus antigenemia, or uniformly elevated IgM serum antibody titers to the complete virions. We propose that herpesvirus EBV, HCMV, and HHV6 immediate-early gene expression in ME/CFS patients leads to host cell dysregulation and host cell apoptosis without lytic herpesvirus replication. Specific antiviral nucleosides, which alleviate ME/CFS, namely valacyclovir for EBV ME/CFS and valganciclovir for HCMV/ HHV6 ME/CFS, inhibit herpesvirus DNA polymerases and/or thymidine kinase functions, thus inhibiting lytic virus replication. New host cell recruitment thus ceases. In the absence of new herpesvirus, nonpermissive herpesvirus replication stops, and ME/CFS recovery ensues. Keywords: ME/CFS, EpsteinBarr virus (EBV), human cytomegalovirus (HCMV), HHV6, abortive replication www.dovepress.com/getfile.php?fileID=8921 www.dovepress.com/a-paradigm-linking-herpesvirus-immediate-early-gene- expression-apoptos-peer-reviewed-article-VAAT - Cached Is there someone with science background who could read this and break it down? It's difficult to understand. Please and Thank You.