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A Pair of Identical Twins Discordant for ME/CFS Differ in Physiological Parameters and Gut Microbiom

Discussion in 'Latest ME/CFS Research' started by Kyla, Oct 11, 2016.

  1. Kyla

    Kyla ᴀɴɴɪᴇ ɢꜱᴀᴍᴩᴇʟ

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    http://www.amjcaserep.com/abstract/index/idArt/900314

     
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  2. RogerBlack

    RogerBlack Senior Member

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    The biome results - is there actually enough understanding of this to say which of two biomes is 'better', or reflective of a disease state. Diet can massively change the biome as an example, as can exposure to outside influences - both of which may vary in a severely affected CFS patient.
     
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  3. Aurator

    Aurator Senior Member

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    As they say, they need to do a bigger study on twins.

    I'm a monozygotic twin, with a healthy other half, and would like to know where I went wrong to get what I've got. We both tended to get the same illnesses and even have the same kinds of accidents while we were growing up.
     
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  4. Cheesus

    Cheesus Senior Member

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    It would be good if you and your twin could sign up to a biobank, as I am sure monozygotic twins are in hot demand:

    http://solvecfs.org/biobank/
     
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  5. alicec

    alicec Senior Member

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    There seems to be a universal finding that less diversity is associated with a variety of health problems and western guts in general are less diverse than those of people eating traditional diets, not to mention the few examples of traditional hunter gatherers.

    I haven't had a chance to read the detail of the study yet - am particularly interested in the virome study.
     
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  6. Cheesus

    Cheesus Senior Member

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    @alicec Would I be correct in thinking that prokaryotic viruses are the same thing as bacteriophages?
     
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  7. alicec

    alicec Senior Member

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    Yes. A phage is a virus that infects a bacterium. I am not sure if the same term is used for a virus which infects an archaeon (also a prokaryote). Archaea are present in the gut though in small amounts compared with bacteria.
     
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  8. Sea

    Sea Senior Member

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    I would be surprised if 34 year old healthy twins had the same microbiome. Has there been any study of that?
     
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  9. alicec

    alicec Senior Member

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    There does appear to be a heritable component to the microbiome - ie host genes play a role. Here is a report of an interesting recent study.
     
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  10. RogerBlack

    RogerBlack Senior Member

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    There is.
    But after you've moved out and not been living with someone for a decade, it looks lots less similar.
    No useful cite other than it was mentioned on this week in virology.
     
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  11. alicec

    alicec Senior Member

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    The recent twin study found that at least a dozen microbes are heritable and that these are temporally stable.
     
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