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A new hypothesis of chronic fatigue syndrome: Co-conditioning theory.

Discussion in 'Latest ME/CFS Research' started by shrewsbury, Mar 28, 2010.

  1. shrewsbury

    shrewsbury member

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    kelly posted this to co-cure today

    [if: ???? does sound a bit pavlovian]

    *A new hypothesis of chronic fatigue syndrome: Co-conditioning theory.*

    Tanaka M, Watanabe Y.

    Department of Physiology, Osaka City University Graduate School of Medicine,
    1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.

    Chronic fatigue syndrome is an illness characterized by a profound,
    disabling, and unexplained sensation of fatigue lasting at least 6months,
    which severely impairs daily functioning and is accompanied by a combination
    of non-specific symptoms.

    Many potential causes of chronic fatigue syndrome
    have been investigated, including viral infections, immune dysfunctions,
    abnormal neuroendocrine responses, central nervous system abnormalities,
    autonomic dysfunctions, impaired exercise capacities, sleep disruptions,
    genetic backgrounds, psychiatric abnormalities, personality, and abnormal
    psychological processes. However, no etiology, specific physical signs or
    laboratory test abnormalities have been found.

    It is essential to establish
    a conceptual theory of chronic fatigue syndrome that can explain its
    pathophysiology in order to identify the clinical entity and to develop
    effective treatment methods. In this article, a new conceptual hypothesis
    about the pathophysiology
    of chronic fatigue syndrome, the co-conditioning
    theory, is presented: after repetitive overwork and/or stress, alarm signal
    to rest and fatigue sensation may cause in response to an unconditioned
    stimulus (impaired homeostasis and function) that has been paired with a
    conditioned stimulus (overwork and/or stress)
    .

    In the future, a new
    treatment strategy for patients with chronic fatigue syndrome,
    re-co-conditioning therapy, may be developed on the basis of the
    co-conditioning theory. In addition, this theory will likely contribute to a
    better understanding of the pathophysiology of chronic fatigue syndrome.

    Med Hypotheses. 2010 Mar 23. [Epub ahead of print]

    Copyright 2010 Elsevier Ltd. All rights reserved.
  2. George

    George Guest

    Huh . . . So I guess they smoke crack even in Japan. Thats a shame.
  3. Koan

    Koan Be the change.

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    Good dog, George.
  4. cfs since 1998

    cfs since 1998 *****

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    They will publish anything.
  5. Koan

    Koan Be the change.

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    I sometimes teach meditation. I'm always wondering how I could use meditation to address ME. I would like to become a Laughter Yoga Leader and use Laughter Yoga with people with ME. (No, I can't stay upright long enough to do any of the above but, for the purposes of this post, that's beside the point :D )

    I'm not surprised when people in various disciplines try to apply their education, theories and techniques to ME. Sometimes it's a good hearted effort. Sometimes it's drumming up business. And, sometimes, when people are employed by international insurance companies or governments reluctant to pay benefits, it's something darker.

    I don't know what this is except it seems old fashioned and wrong headed. Haven't we already mined this ground for all it's worth?
  6. Dolphin

    Dolphin Senior Member

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    I read somebody's critique of this paper (can't be reposted unfortunately). They weren't impressed.
    They said: "Treatment is CBT/GET to stop you resting. Then you get pleasant fatigue instead of unpleasant fatigue."
  7. Dr. Yes

    Dr. Yes Shame on You

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    Et tu, Osaka? I thought Japan had a more sophisticated approach to ME/CFS. Sounds like they're just beginning to discover the psycho lobby literature.

    (I hope you all appreciate how hard it was for me not to post an image of Godzilla.)

    :innocent1:
  8. Athene

    Athene Never give up

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    Italy
    They're not talking about us in this document, are they?
    It's about people whose main symptom is an "unexplained sensation of fatigue" and other "non-specific symptoms". Not me, mate! My main symptom is post-exertional hypoxia explained by mitochondrial dysfunction, and all my other symptoms are highly specific.
    I think they are just talking about over-stressed Japanese executives. People with Reeves syndrome and Wessely Disease.
  9. Gerwyn

    Gerwyn Guest

    Methinks he wantabe rich and wantabe shot is it Tan AKA wesselly
  10. Jerry S

    Jerry S Senior Member

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    Chicago
    Dear Dr. -

    Do not constrain thyself.

    Best wishes,

    A congregant of the Church of FIB
  11. Cort

    Cort Phoenix Rising Founder

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    It sounds like that vaunted Japanese effort is striking out. They didn't have much to report at the IACFS/ME conference either.
  12. fingers

    fingers Senior Member

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    SW Endland
    Agree, Athene, I think this is the root of the problem. We need to get away from "fatigue".

    The stuff Tomk posted about clinician training was centred around this too.

    Unfortunately, it's even the central part of the name now....CFS

    How about we retain CFS, but change it to Continually Feeling Shit ?

    CALL TO ACTION : Whatever you do, don't tell 'em you're tired.

    F
  13. Gerwyn

    Gerwyn Guest

    how about dropping the name altogether
  14. fingers

    fingers Senior Member

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    Agree too Gerwyn, just trying to add a touch of humour (in the absence of intelligence on my part).

    What do you think the name should be (maybe XAND for some soon, but will then need a name for "the rest").

    How important do you think the name is and how feasible is it to achieve a change?

    To my mind (restating what I said previously), definitions, classifications and diagnosis are at the root of misunderstandings about appropriateness of psychiatric approaches. The whole thing is inadequate, and the inability of the medical profession to grasp this problem and to solve it is woeful.
  15. PoetInSF

    PoetInSF Senior Member

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    SF
    There could be something to this, given that many of us are hyper-reactive to stress, exertion, chemical or stimuli. But I would question how we get into that conditioned state to begin with. It could be an injury by one time stress, like viral infection or other trauma, as well as conditioning by repeated stress.
  16. cfs since 1998

    cfs since 1998 *****

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    What? Because two people who happen to be Japanese write a paper in Medical Hypotheses that means the entire country's efforts are "striking out"? This makes no sense.
  17. Gerwyn

    Gerwyn Guest

    psychatrists dontmake diagnoses only real doctors do that.psychiatrists just categorise and stigmatize
  18. fingers

    fingers Senior Member

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    Is it me, or am the above nor English....maybe Japanese?

    FWIW - here's finger's feory (UK has now dispensed with "th" in favour of "f" - they teach this in schools - my nickname is actually thingers).........

    When we're happy and swinging along we don't get ill.

    So, if we're infected with HIV, maybe it hangs around waiting until we're below par, then does it's stuff. Maybe same with XMRV.

    However, once "lifetime" hitchhikers such as these get in there, we can't get rid of them. It doesn't matter if we reduce our stress to zilch, eat well, rest - we can feel better, sure, but the underlying condition doesn't change - unlike having "temporary" viruses such as a cold, or more benign lifetime ones like herpes.

    So, psycho approaches can only help with temporary infections, or problems with a psychiatric bias, and these things may simply go away anyway, so difficult to prove efficacy of the approach.

    T
  19. Gerwyn

    Gerwyn Guest

  20. fingers

    fingers Senior Member

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    SW Endland

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