The Power and Pitfalls of Omics: George Davey Smith’s storming talk at ME/CFS conference
Read about the talk that stole the show at a recent ME/CFS conference in Simon McGrath's two-part blog.
Discuss the article on the Forums.

A new case definition of Neuro-Inflammatory and Oxidative Fatigue (NIOF), a neuroprogressive...

Discussion in 'Latest ME/CFS Research' started by Kyla, Oct 17, 2015.

  1. Kyla

    Kyla ᴀɴɴɪᴇ ɢꜱᴀᴍᴩᴇʟ

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    http://europepmc.org/abstract/med/26454487

    So...researchers are just making up their own diagnostic criteria and names now?


    Seems to be just an abstract at the moment:

     
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  2. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    What a terrible name haha.. Why not call it "intolerant and fatigued" (IAF)...
     
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  3. John Mac

    John Mac Senior Member

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    "New ME/CFS case definitions based on consensus criteria among experts are largely inadequate, e.g. those of the US Institute of Medicine ."

    Wow, what an arrogant statement.
     
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  4. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    Had me scratching my head as well..
     
  5. Snow Leopard

    Snow Leopard Hibernating

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    Well at least one is...

    Indeed. this one doesn't exactly tick the all the boxes for development of a rigorous diagnostic criteria.
     
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  6. TiredSam

    TiredSam The wise nematode hibernates

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    No mention of PEM.
     
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  7. Marco

    Marco Grrrrrrr!

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    Funny how you can guess the author from the title.
     
  8. Snow Leopard

    Snow Leopard Hibernating

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    No one else wanted to put their name on this one. ;)
     
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  9. Jonathan Edwards

    Jonathan Edwards Senior Member

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    "Consensus is inadequate, you can only rely on the opinion of ... well me actually."

    Fortunately, I suspect he is talking to himself.
     
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  10. A.B.

    A.B. Senior Member

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  11. msf

    msf Senior Member

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    I doubt it, Prof. Edwards, seeing as Fluge and Mella seem to be reading his papers. I think a potential advantage that this criteria has over others is that it uses biomarkers to define it. You can argue about the biomarkers, but that seems to me to be a step forward - I´m sure people would be praising Lipkin et al if they used the cytokine studies to come up with their own criteria. Also, pointing out that the existing criteria are problematic is hardly controversial - a lot of threads on new studies ends up with a debate about critera. Finally, it may be a stupid name, but is it stupider than SEID?
     
  12. John Mac

    John Mac Senior Member

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    "formerly known as chronic fatigue syndrome or Myalgic Encephalomyelitis"

    Not just coming up with a new definition but retiring the "former" ones as well.
     
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  13. Snow Leopard

    Snow Leopard Hibernating

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    Tail wagging the dog. These proposed biomarkers aren't exactly, well,,,, reasonable or valid at this point in time.
     
  14. msf

    msf Senior Member

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    They aren´t reasonable or valid to you, but they are to Maes, and possibly KDM too.
     
  15. Jonathan Edwards

    Jonathan Edwards Senior Member

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    That I think about sums it up.

    What if these criteria were accepted and you (one of the people in the study with CFS who did not overlap with NIOF) go to a GP and she says 'ah but your anti-oxidised IgM thingy is normal so you don't have Inflammo-oxidative-fatiguy-thingy-flapdoodly-disease so you can go back to work and shut up' just as GPs have for decades been telling people with rheumatoid arthritis that because their rheumatoid factor is negative they have nothing wrong with them? People on PR tell me they have a serious illness. How does it stop being a serious illness because some lone Dutchman says they have to have antibodies that nobody else has ever measured?
     
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  16. msf

    msf Senior Member

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    You mean so you don´t get any of that excellent treatment on offer?
     
  17. msf

    msf Senior Member

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    And I believe Maes and KDM know vastly more about ME than anyone on this forum.
     
  18. msf

    msf Senior Member

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    Oh, and where does he say it stops being a serious illness?

    And Maes is Belgian.
     
  19. mango

    mango Senior Member

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  20. msf

    msf Senior Member

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    Thanks Mango.
     
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