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ME/CFS and the Magic of the Canine Factor
There's been plenty of research indicating that having pets is good for your health. I never really noticed any particular benefits to having cats, though that may have had more to do with my cats. They've been fairly indifferent to my presence and we've shared a live-and-let-live...
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A Neuroinflammatory Model of ME/CFS

Discussion in 'Latest ME/CFS Research' started by Marco, Jan 17, 2013.

  1. Marco

    Marco Old blackguard

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    Hello all

    Just to let you know that I have just put up a 'guest blog' on Cort Johnson's new site HealthRising.

    This is part I of a four part series which puts forward a new hypothesis for ME/CFS based on a review of ME/CFS literature and literature from other 'neuroinflammatory' conditions.

    The 'blog' will be presented in four parts over the coming weeks :

    Part I – Sensory Gating

    Part II - Glutamate - One More Piece in the Puzzle?

    Part III - Glutamate/GABA Imbalance – Stiff Person Syndrome

    Part IV - Symptoms, heterogeneity and onset

    Please pop over and have a look.:)

    Regards Marco
    Sam Carter, MishMash, Merry and 7 others like this.
  2. Enid

    Enid Senior Member

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    Great to see Marco - I'm following. So much in the way of pathologies already known - putting the whole puzzle together very absent.
    Marco likes this.
  3. madietodd

    madietodd Senior Member

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    Great article..........I can't wait to see the rest.
    Marco likes this.
  4. Marco

    Marco Old blackguard

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    Thanks Enid and Maddie:)
    Enid likes this.
  5. anne_likes_red

    anne_likes_red Senior Member

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    Good work Marco.
    Impressive.
    :)

    ETA: Is it just me, or does anyone else fit the "sensory gating gone awry" criteria?
    I had infectious onset (in 1984), but I only have to look at my very first school report "Anne does better in a small group, and she's not so comfortable in the big room" to wonder about predisposing factors.
    FWIW :D By the time my second school report was out, I'd moved from a big inner city school with open plan classrooms to a little country school and was much more comfortable.
    Marco likes this.
  6. madietodd

    madietodd Senior Member

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    Anne, your early report also fits with being an introvert, and/or "highly sensitive." Maybe that's what you're saying......that some of us with these traits are predisposed to sensory gating problems.
  7. anne_likes_red

    anne_likes_red Senior Member

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    madietodd I guess so, or underlying genetics even? :)
    katim likes this.
  8. Lynn

    Lynn Senior Member

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    Nice article Marco. Thank you.

    Until the illness, I was very much an extrovert. Yet I fit the description of sensory gating problems to a tee. I have problems with sound smell and am sensitive to touch. I often think that if I could control the sensory overload, I would feel a lot better.

    Lynn
  9. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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  10. Marco

    Marco Old blackguard

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    I appreciate the 'likes" but please pay a visit and give it a yeah! or nay!
  11. ramakentesh

    ramakentesh Senior Member

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    i definately think it is a neuroinflammatory disease - however there is evidence that small fibre neuropathies are cytokine-driven as is potentially NET gene silencing - both of which have at least been identified in POTS and OI.
  12. Enid

    Enid Senior Member

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    I'm no biologist but are not cytokines especially produced in the presence of some biological morbidity. Deep infection.
  13. PhoenixBurger

    PhoenixBurger Senior Member

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    Quercetin inhibits inflammatory cytokines.

    But you don't want to be inhibiting cytokines if you're in the process of fighting an infection. You need them.

    That's where this becomes annoying. One could take Quercetin and do some good if there is no pathogen causing this.

    One could take Quercetin and do some bad if there is.

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