Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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A narrative review on the similarities and dissimilarities between ME/CFS and sickness behavior

Discussion in 'Latest ME/CFS Research' started by Ember, Mar 8, 2013.

  1. Ember

    Ember Senior Member

    Authors: Gerwyn Morris, George Anderson, Piotr Galecki, Michael Berk and Michael Maes

    Credits/Source: BMC Medicine 2013, 11:64 doi:10.1186/1741-7015-11-64

    Published on: 2013-03-08
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  2. Valentijn

    Valentijn Activity Level: 3

    I think these sorts of articles are great ... they might not look like much on their own, but they should provide strong support (as cited sources) for future publications.
  3. Ecoclimber

    Ecoclimber Senior Member

    Unloaded PDF of the article.


    It is of importance whether myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a variant of sickness behavior. The latter is induced by acute infections/injury being principally mediated through proinflammatory cytokines. Sickness is a beneficial behavioral response that serves to enhance recovery, conserves energy and plays a role in the resolution of inflammation. There are behavioral/symptomatic similarities (for example, fatigue, malaise, hyperalgesia) and dissimilarities (gastrointestinal symptoms, anorexia and weight loss) between sickness and ME/CFS. While sickness is an adaptive response induced by proinflammatory cytokines, ME/CFS is a chronic, disabling disorder, where the pathophysiology is related to activation of immunoinflammatory and oxidative pathways and autoimmune responses. While sickness behavior is a state of energy conservation, which plays a role in combating pathogens, ME/CFS is a chronic disease underpinned by a state of energy depletion. While sickness is an acute response to infection/injury, the trigger factors in ME/CFS are less well defined and encompass acute and chronic infections, as well as inflammatory or autoimmune diseases. It is concluded that sickness behavior and ME/CFS are two different conditions.


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