Jen Brea launches mass-advocacy platform — #MEAction goes live!
Jen Brea is a phenomenon. After working as a freelance writer in China and Africa, she enrolled for a PhD at Harvard in political science but, four years ago, got sick. She had a fever that lasted ten days.
Discuss the article on the Forums.

A narrative review on the similarities and dissimilarities between ME/CFS and sickness behavior

Discussion in 'Latest ME/CFS Research' started by Ember, Mar 8, 2013.

  1. Ember

    Ember Senior Member

    Messages:
    2,055
    Likes:
    2,269
    Authors: Gerwyn Morris, George Anderson, Piotr Galecki, Michael Berk and Michael Maes

    Credits/Source: BMC Medicine 2013, 11:64 doi:10.1186/1741-7015-11-64

    Published on: 2013-03-08

    http://7thspace.com/headlines/43378...gue_syndrome_mecfs_and_sickness_behavior.html
     
    heapsreal, Shell and Valentijn like this.
  2. Valentijn

    Valentijn Activity Level: 3

    Messages:
    8,707
    Likes:
    15,791
    Amersfoort, Netherlands
    I think these sorts of articles are great ... they might not look like much on their own, but they should provide strong support (as cited sources) for future publications.
     
  3. Ecoclimber

    Ecoclimber Leaving for awhile

    Messages:
    807
    Likes:
    1,639
    Unloaded PDF of the article.

    Abstract

    It is of importance whether myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a variant of sickness behavior. The latter is induced by acute infections/injury being principally mediated through proinflammatory cytokines. Sickness is a beneficial behavioral response that serves to enhance recovery, conserves energy and plays a role in the resolution of inflammation. There are behavioral/symptomatic similarities (for example, fatigue, malaise, hyperalgesia) and dissimilarities (gastrointestinal symptoms, anorexia and weight loss) between sickness and ME/CFS. While sickness is an adaptive response induced by proinflammatory cytokines, ME/CFS is a chronic, disabling disorder, where the pathophysiology is related to activation of immunoinflammatory and oxidative pathways and autoimmune responses. While sickness behavior is a state of energy conservation, which plays a role in combating pathogens, ME/CFS is a chronic disease underpinned by a state of energy depletion. While sickness is an acute response to infection/injury, the trigger factors in ME/CFS are less well defined and encompass acute and chronic infections, as well as inflammatory or autoimmune diseases. It is concluded that sickness behavior and ME/CFS are two different conditions.

    Eco
     

    Attached Files:

    Ember likes this.

See more popular forum discussions.

Share This Page