Mouse Model of ME/CFS I was thinking that a murine model of ME/CFS might be possible. Such a model could significantly speed up research into the pathophysiology of ME/CFS, since murine nervous systems could be dissected and closely examined for viral infection, etc, and it should then be possible to work out exactly the areas in the brain are compromised in ME/CFS. One question with such a murine model is how can you know that a mouse has ME/CFS? Well, since ME/CFS has two very characteristic symptoms of cognitive dysfunction (brain fog) and post-exertional malaise (PEM), mice that have been injected with viruses and bacteria in order to precipitate ME/CFS could be put through simple maze tests and so forth to see if the mice have acquired the these two characteristic symptoms. Brain fog involves cognition dysfunctions such as poor short-term memory, poor working memory, and frequent miscategorisation of objects or stimuli (like answering the phone when the doorbell rings!). Even in mice, these types of basic cognition difficulties should be measurable and quantifiable through standardized maze and similar tests. Although brain fog also occurs in other diseases as well, the brain fog of ME/CFS is quite unique in that it worsens significantly as a result of post-exertional malaise, and this fact should be easily verifiable in mice, simply by pushing these mice through lots of exertion, and noting their increasing brain fog and declining cognitive performance on maze tests. Once you have shown that the mice have quantifiable brain fog which also significantly worsens after exertion, you should be able to conclude with confidence that these mice have ME/CFS. One could presumably use this murine model of ME/CFS to learn what types of combinations of microbial infections can precipitate ME/CFS in the first place. For example: from the human statistical data on ME/CFS, we know that prior conditions/infections like IBS/SIBO, chronic recurrent urinary tract/kidney infections, interstitial cystitis and overactive bladder are common in ME/CFS patients, and thus may conceivably predispose a person to acquiring ME/CFS. But there is no direct proof that these prior conditions/infections do play a causal role in ME/CFS; all we know at the moment is that these prior illnesses are statistically co-morbid conditions of ME/CFS. Thus it would be very interesting to see if mice too, if given such prior conditions like a chronic kidney infection, would then more easily develop ME/CFS when later given a enterovirus or herpesvirus infection. This is one example of how a murine model of ME/CFS could provide invaluable data on the etiology of this disease.