Hello Friends! My husband and I decided to go down the 23andme road since he tested positive for MTHFR C677T through our doctors office. He is always tired, depressed, and suffers from chronic pain (damn drunk driver whom plowed into him). I on the other hand suffer from Endometriosis, Adenomyosis, IC and have basically always been sick (bronchitis) or felt sick. More recently (since my last surgery) I have been loosing my vision/getting blurry vision to the point of not being able to do anything. I am REALLY hoping that changing some things in our household/foods/vitamins will help us feel better! My yellow and red results are...(no point to add green) Methylation Profile VDR Bsm rs1544410 CT +/- VDR Taq rs731236 AG +/- MAO-A R297R rs6323 TT +/+ MTHFR C677T rs1801133 AG +/- MTHFR A1298C rs1801131 GT +/- MTRR A66G rs1801394 GG +/+ MTRR A664A rs1802059 AG +/- CBS C699T rs234706 AG +/- CBS A360A rs1801181 AG +/ Detox Profile GSTT1 Present From what I understand, the +/- or yellow results are things that may or may not effect me. The +/+ or red ones do effect me and I need to handle to feel better. GSTT1 is an enzyme that I am lacking. This increases my risk of mercury and xenobiotic toxicity. My question is, how do you help an enzyme that you don't have? MTRR A66G mutation will be helped by taking methyl-B12 supplements. NEEDS FOLATE VDR = Need's Vit D supplementation My Husbands results... Methylation Profile COMT V158M rs4680 AG +/- COMT H62H rs4633 CT +/- VDR Taq rs731236 AA +/+ MAO-A R297R rs6323 TT +/+ MTHFR C677T rs1801133 AA +/+ MTR A2756G rs1805087 AG +/- MTRR A66G rs1801394 AG +/- BHMT-02 rs567754 CT +/- BHMT-08 rs651852 CT +/- CBS C699T rs234706 AG +/- CBS A360A rs1801181 AG +/- Detox Profile CYP1B1 L432V rs1056836 CG +/- CYP1B1 N453S rs1800440 CT +/- CYP1B1 R48G rs10012 CG +/- CYP2C19*17 rs12248560 CT +/- CYP2E1*1B 9896C>G rs2070676 CG +/- SOD2 A16V rs4880 AG +/- NAT2 G286E rs1799931 AG +/- GSTT1 Present We have a few over lapping mutations and it seems like some of the mutations either don't have much information (that I can find) or there isn't much difference between the mutations. Would anyone be kind enough to help me understand these more and/or some pointers on which vitamins/supplements to take? I greatly appreciate it!