I rather suspected I'd get some questions on that front from people desperate for some of the same. I'm afraid my mileage probably varies so much that it won't be much use to many others to say how things worked out for me, and really it's a long and complicated story, but I'll try to summarise how it went for me... I remember the first night in many years when I had good quality sleep: it was my first night on a very expensive new Tempur mattress. I slept for 6 hours and woke up feeling filled with unbelievable energy (as opposed to feeling like a truck had run over me during the night), and aware of having dreamed for the first time in many years. I had a couple more nights of good sleep, but then the itching gradually began to resume and after a month or two I couldn't sleep in that bed at all - but I did get a big long-term boost from having slept successfully even just for a couple of nights for the first time in many years. In particular, my long-term back and neck problems had gone, after 10 years of unsuccessful treatments with various therapies. It wasn't as simple as that of course; the long-term issues remained and still fluctuated to a greater or lesser extent, but I did have a strong clue as to how sleep was affecting me, and what it resolved and what it didn't resolve. The direct answer to how I got that deep sleep, really, is that I can't say for sure because it came during a year when I was literally trying everything I could think of and spending all the money I had left on all kinds of things. But there were 2 or 3 factors that really stand out. First, for the whole of that year I was following a treatment plan from an associate of Dr Myhill's, as a result of Biolab tests that identified chemical sensitivities. I eliminated synthetic chemicals in cleaning products, washing up liquid etc, and replaced with natural solutions. I went on an eilimination diet and ended up eating nothing but beef, potatoes and peas, and then also fruit smoothies, cheese and dark chocolate, for about a year. I was taking about 20 supplement pills a day - Co-Q10, B12, Omega-6, L-carnitine, zinc, multi-vitamins etc. (the supplements and the diet were both targeted specific to my sensitivities and deficiencies based on the biolab tests). I started filtering my drinking water. For most of these changes, I introduced them one at a time so I could see which affected which symptoms, and I'd say that B12, Co-Q10, and elimination of washing up liquid and washing powders in favour of natural solutions, were the most obviously beneficial. But then, the other major issue for me was getting a safe haven where I didn't itch in contact with what I was wearing or sleeping on. That was incredibly difficult. The new tempur mattress was a great solution to that (neuropathic?) pain that only lasted a few days. The longer-term solution came from a semi-aniline leather sofa. Semi-aniline because, being a natural flame retardant, it didn't have to be treated with flame retardant chemicals which were and are my biggest sensitivity causing the itching and burning; stuff in washing up liquid is the second biggest sensitivity on both tests and my personal experience. Gluten free was also very significant. For about a couple of years, I slept naked on the leather sofa with the heating whacked right up. That was the only way I could sleep without itching. Once I could do that, I could sleep properly: it was my oasis. 90% of my time is still spent on this sofa, but at least now I can wear some clothes. I still don't get great sleep, and I still have a degree of the itching/burning reaction most of the time, but it's massively lower level than it used to be and I generally sleep much better. I still get the same reactions if I try to return to a bed or wear general clothes though. How does this apply to anyone else? It probably doesn't apply directly to many people. I haven't found many people who have the same kind of itching/burning that I have, although Prof Baraniuk has described it as a relatively rare subset of ME/CFS in which the itching/burning is equivalent to the muscle and joint pains (I get muscle pain as well when I'm very ill, but never very much joint pain). I think it's a rare subset and if we understood all these conditions medically it may well be a different condition to ME which has many similar symptoms. But anyway, the main conclusion I've reached is that when I'm experiencing certain types of pain (itching/burning) then I just don't enter deep sleep. What seems to happen is that after I haven't slept at all for 48 hours, I become able to fall asleep in a kind of paralysis: I sleep for 14-18 hours but I don't think I'm ever entering deep sleep. When I wake, in the exact same position I fell asleep in (I tested this) sensation returns very slowly, and when it does, the itching/tingling/burning gradually resumes - and I feel absolutely shattered after such a sleep. So I just think there are certain types of pain - which may be so low-level you don't necessarily even notice them - which are constantly active (itching away and constantly sending nerve signals) which can prevent you from entering deep sleep. Then, if that pain is just constant, and becomes so constant that you may even become numb and not consciously be aware of it, then you are constantly unable to enter deep sleep. When that happens, nothing ever heals overnight (cognitively or physically); muscles don't recover from rest and so back pain becomes chronic because ordinary daytime activity never gets its rest and recovery period. All kinds of problems are unable to heal simply because they never ever get their natural rest and recovery period. That's just my own mileage: I really don't know how generally applicable it is. All I know for sure is that certain types of chronic pain can prevent restful sleep, and this can go on for decades, and when that happens, your body never heals and the consequences of all that can include almost any of the symptoms of ME/CFS. So, as a hypothesis, I would suggest that it's possible for other kinds of chronic pain and chronic neuropathy to cause this situation, and it is even very much possible, from my experience, that sufferers may not be consciously aware of that chronic neuropathic pain if they have become numbed to it, or if other types of pain are masking it, and so it's possible that this whole basic pattern could be a common factor in many diverse causes of the same or similar symptomology. One last caveat: although there is an obvious potential vicious cycle here (if you can't heal overnight, that could be the reason why the chronic pain continues), and one might therefore guess that could mean the whole thing is just a vicious cycle, in my case and I think for most of us, we know that there is also something underlying it all which is more fundamental and permanent. If it were just a vicious cycle and nothing more, we'd break out of it by chance sooner or later. But in my case, I know that even after I've made a very significant recovery and become largely symptom-free most of the time, and despite often getting decent sleep, nevertheless even after a few weeks or (very rarely) months of no noticeable burning/itching, if I just spend an hour or so sitting on the wrong kind of chair, the whole thing comes right back again. I have to avoid all the triggers constantly (though not 100%, I have more tolerance now and can do all these things for a short time before the effects build up), and no matter how 'de-toxed' or apparently healthy I get, the basic problem remains: the reaction has never changed, all that has really changed is that I avoid the triggers. So I still haven't cured 'it' but I've learned to live better with 'it'. And I really feel for all of you reading this who haven't made such progress, because I know it is an unimaginable hell to anyone who hasn't experienced it. I really don't know whether any of what I have, or what has helped me, is directly applicable to others, but I do know that it took years and years, and thousands of pounds of treatment and thousands of pounds of expenditure, and constant experimentation, for me to slowly improve inch by inch, with constant setbacks. So I think it is possible that the same could all be true for some others, but of course it's also possible that I just have something different and none of this will work for you. And finally, I'm afraid to say that the list of possible triggers is probably endless, and I do suspect that hormones may themselves be a trigger for many of us, in which case women in particular who are in the situation I've hypothesised really may have little or no chance of escaping from their triggers in this way. All of the 'recovery' stories I've heard that are of a similar pattern to my own are males, as far as I can recall. So perhaps all that is not very encouraging or helpful, in the end, but that's my experience anyway.