Lotus Thanks yes its a lonely life having ME. But even if I showed my family my 23andme results they would just say that they have similar genes and dont have `yuppie flu`. I was taking a tiny scrap of an active b multi but had a huge increase of depression and histamine. Today I took 25mcg hydroxb12. Maybe I should try folonic acid. Am doing well on a macrobiotic diet. It nicely balances my neurotransmitters.