PACE data implies annual Societal cost of CFS around £1 billion £4.3 billion [corrected] Using the PACE data for baseline costs (just for CBT, but the other 3 groups were similar), which is £21,600 higher than that for recoverd patients, and the UK adult population (aged 18+) of 49.7m gives an annual cost of CFS patients of £1,072,000 million This excludes extra costs for those more severely affected and costs for those under 18. However, around half of those aged 18-21 will be in full-time education, but these figures give you an idea of the likely overall costs: pretty big. The figures are also based on those with an average illness duration of around 3 years, which might not be representative of the wider CFS population. Of course, most of these costs are borne by the patient, not the state, but the state will have substantial costs though lost taxes and extra benefit payments, and higher healthcare costs. Then, of course, there are the human costs.