i have been trying to get this methylation thing right for quiet some time. it has mostly backfired. i started offf with jarrow methyl b12 and folate then moving on to thorne and now on solgar. NADA. everytime i will get this supreme potassium hunger with none of the good stuff. then i recently moved to pure encapsulations and it did create a world of difference for me. now its possible that it may have some fillers that you might not like. but the case in point is that please dont give up with one brand. try a different brand of folate/b12 and something might just click. I can definitely recommend pure encaps though.