Hi Stridor and Howirecovered, It'a about time for a design I have worked on for a long time, starting back in the late 70s. I did some consulting for a new HMO designing their computer system. The HMO director had the computer as his brainchild and was doing the design. After suddenly retired for health reasons, I was called in to review what was going on and get the new director up to speed. We explored some data mining ideas and rapidly ran into space problems. Megabytes used to be considered a lot of room. The type of program I had in mind needed gigabytes or more for the data. Now anybody can buy disk space by the terabyte. The type of program I want to write and have partially designed would take all the SNPs and other information, everything we are already working with; symptoms, side effects, therapies and so on and see what patterns match up. So we might be able to answer the question of why persona x and y react in opposite ways to a given item. Suppose we are 10 or 20 years ahead of our time Suppose it is more like 100 years ahead of our time in certain ways. For instance, one of the problems for all of us here is that 60+ years of research has been done on folic acid and CyCbl/HyCbl. As those are not kinds the body actually works with, they produce different results with everything, other vitamins for example. B1, b2 and b3 and what they do with the REAL b12s, AdoCbl and MeCbl and the real animal folate l-methylfolate. It gets that basic and our nutritional science has no idea at all. Most all the data in recent decades is contaminated by folic acid, CyCbl and HyCbl. It is near impossible to get a study approved using 3 substances. How long until they allow one with all four of the deadlock quartet on sick people. Testing it on well people will only show it does nothing for them. Then they will freak out at the thought of adding potassium, titrating methylfolate, having all the basic vitamins and minerals and also titrating some of those for adjustments. They just don't do studies of a combination of 30 or 40 things in floating ratios. Something like the Active B12/folate Protocol is impossible to come out of the medical industrial complex because nobody wants $50 worth of vitamins turned into $1000/month with of medical foods and they won't do they research if billions and billions in payoffs are not there. Also, it is just plain against the whole study a single substance" idea. That doesn't work at all. Nutrition isn't medicine. We are not looking for one miracle drug to overcome whatever is happening, like an antibiotic, to make us well. Instead we are looking for how to replace the real vitamins removed from our food and replaced with fake vitamins that do so very little other than microscopic responses. THEY DON"T HEAL. All this to be replaced with drugs to fix 1000 problems with maintenance pricing at that magic $500/month per drug price point Anybody every have antibiotics here? I have. When they work, they work quickly, no lab tests looking for micro results to see if the person got well. When they don't work is when they have to look closely to see that is going wrong. People can get well with AdoCbl, MeCbl, L-methylfolate and LCF plus all need cofactors in the correct balance and there-in lies the problem. .