This thread is meant to discuss the experiences of ME patients with high doses of the separate b vitamins. It is NOT a methylation thread, therefore I posted it on the general treatment section. Many supplements nowadays include high doses of the b-vits. The arguement is that, as they are soluble, more cant hurt. Unfortunately this is not true. I got neuropathy from the soluble b6, and even its 'harmless' form of p5p, and im not the only one For an excellent overview of the effects of high doses of the B's see http://www.acu-cell.com/bx.html I know for me that high b12 and b6 is not good, and worsens numbness. I dont think high dose niacinamide, pantethine helped me. I think high dose thiamin and biotin might be good. Not sure about riboflavin. WHat are your experiences?