Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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A 50,000 Foot Overview of Major ME/CFS Theories

Discussion in 'General ME/CFS Discussion' started by Jesse2233, Nov 15, 2017.

  1. Gemini

    Gemini Senior Member

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    @Jesse2233 many theories from your 50,000 foot overview are aggregated in the Solve ME/CFS 2017 Ramsay Award to the Bergquist et al team:

    Our working hypothesis of ME/CFS pathogenesis is that a person predisposed for ME through genetics and previous antigen exposure is infected with a microbe prone to elicit ME. These microbial antigens have epitopes which cross-react with self-epitopes. An (auto)immune response to this microbe which bypasses tolerance mechanisms is elicited.

    The cross-reactive immune response, e.g. autoantibodies, is directed against molecules involved in energy metabolism, hormonal regulation and, possibly, specific portions of the brain.

    In short, “infection elicited autoimmunometabolic dysfunction”.


    The role of infection may either be a “hit and run” phenomenon, or a chronic infection (“stay and fight”).

    EDIT: Link-- http://solvecfs.org/2017-ramsay-award-program-team-1
     
    Last edited: Nov 19, 2017
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  2. sb4

    sb4 Senior Member

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    You know, if this did turn out to be the cause of ME, I wouldn't even be mad about all the lost years.
     
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  3. w john martin

    w john martin

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    The CFS community has yet to acknowledge data showing that CFS is part of a wider spectrum of brain-damaging illnesses due to infection with stealth adapted viruses. These viruses largely go unrecognized by the cellular immune system because of the deletion or mutation of genes coding for the relatively few virus components that are normally targeted by the cellular immune system. Fortunately, the body is not dependent upon the immune system for protection against infectious agents. There is the alternative cellular energy (ACE) pathway, which is effective in the defense against stealth adapted viruses, as well as conventional viruses. A political barrier to this research is that certain stealth adapted viruses originated from cytomegaloviruses from the types of monkeys used to produce live polio vaccines. The CFS community can learn more about stealth adapted viruses and the ACE pathway by reviewing various online publications. A greater awareness of this research within the CFS community may lead to more directed actions by public health officials and by the leadership in various CFS patient support groups.
     
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  4. Jesse2233

    Jesse2233 Senior Member

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    @w john martin

    Prof Martin, good to hear from you, your theory on the simian cytomegalovirus (SCMV) would be a good addition to the list.

    What treatments do you think best activate the ACE pathway? Might apheresis techniques such as UBI, MAH ozone, and photopheresis be effective?
     
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  5. w john martin

    w john martin

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    Dear Jesse,

    Thanks for asking. The main developments have been in i) showing that the ACE pathway is reflected in a dynamic (kinetic) quality of the body’s fluids; ii) that the energy comes from an environmental force, which I am calling KELEA (kinetic energy limiting electrostatic attraction); iii) administering or consuming activated water can enhance the ACE pathway; and iv) the fluctuating electrical activity of the brain appears to act as a natural antenna for KELEA. Clinical testing is best directed to items iii) and iv). To be meaningful, the studies need to be controlled and IRB approved. Specific suggestions regarding possible therapies are inappropriate on this forum.

    The data on SCMV origin of certain stealth adapted viruses have been unequivocal since first published in 1995. This is the issue that public health authorities should address. They will then benefit from the added bonus of learning more about the ACE pathway.
     
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  6. wastwater

    wastwater Senior Member

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    I can believe in this as a potential cause just not sure about the treatment
    I see large t antigen is a protein
     
    Last edited: Nov 20, 2017
  7. Stretched

    Stretched Senior Member

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    @Prof Martin
    I’ve read your publications in the past... . don’t recall if they covered this, but I’m curious about Tetanus vaccine - any thoughts,
    e.g. in conjunction with stealth viruses or SMV-40, polio vaccines?
     
  8. w john martin

    w john martin

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    Dear Stretched,
    The heightened immune response induced by vaccination, including tetanus vaccine, can potentially trigger tissue-damaging reactions against remaining minor antigens expressed on stealth adapted virus-infected cells. Vaccine provocation of a pre-existing stealth adapted viral infection explains cases of vaccine-induced autism and also the health deterioration in occasional recipients of human papillomavirus (HPV) vaccine.
     
    ScottTriGuy likes this.
  9. ScottTriGuy

    ScottTriGuy Stop the harm. Start the research and treatment.

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    This is new info for me - very interesting.

    Are stealth adapted viruses communicable between people, if so how?
     
  10. Mary

    Mary Senior Member

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    @w john martin - what is "activated water"? Is it something available to the public? I agree with @ScottTriGuy, your theory is very interesting. I read a book a few years ago about contamination of the polio vaccine (Dr. Mary's Monkey). I also recall that it's been linked to mesothelioma.
     
  11. w john martin

    w john martin

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    Dear Scott,
    Stealth adapted viruses are contagious. In addition to animal studies, the evidence comes from “family illnesses of presumptive infectious origin” in which the affected family members have positive virus cultures. The diverse range of clinical illnesses in the families underscores the futility of trying to define CFS as a unitary disease. There are additional examples of occupational and social transmission of infection. One manifestation can be an AIDS-like illness, in which HIV testing is negative. Virus transmission can occur during pregnancy and can lead to autism and other learning/behavioral disorders in the infected children. Public health authorities and certain patient support groups have been hesitant to consider CFS as an infectious disease. This situation may change with an increasing public awareness of stealth adapted viruses and with questions being specifically addressed to public health authorities.
    To Mary, As I noted earlier, specific suggestions regarding possible therapies are inappropriate on this forum. I think it is best to strive towards the public health acknowledgment of stealth adapted viruses; some of which are unequivocally derived from African green monkey simian cytomegalovirus (SCMV).
     
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  12. wastwater

    wastwater Senior Member

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    There are videos on YouTube that explain activated water seems easy to do
     
  13. lior

    lior Senior Member

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    @Jesse2233 thank you so much for this list!! Maybe you should add it to wikipedia - I'm sure it could benefit so many people.

    I actually found this thread because I'm looking for a complete list of treatment possibilities. (Ok, now that I think about it, complete would be impossible.) The idea occurred to me to crowdsource a big list of treatments people have tried, from b12 to the Lightning Process to CBT to reki and everything else, irrespective of evidence and popularity.

    It's taking me ages to compile this list for myself, so maybe we can take out the hard work for future people in my position. Although... I kind of hope this list is already made, somewhere? Does anyone know?

    My intention would be to slowly research my way through the list, and make a copy of it so that I can note how effective each treatment was for me. I'm guessing plenty of people out there have got a list like this that they're keeping for themselves?

    PS I'm quite interested in self-measurement systems, so if anyone is interested in telling me how they've structured theirs, please get in touch. My feeling is that there's scope for designing a self experimentation spreadsheet (and maybe one day an app) that could be freely available.
     
  14. Jesse2233

    Jesse2233 Senior Member

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  15. lior

    lior Senior Member

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    Thank you @Jesse2233 ! Much more advanced than I even imagined. How wonderful :) I'm going to contact them and offer my design skills... for when I'm having a better month.
     
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  16. Zara

    Zara

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    Hi


    Based on different research publications on me/cfs and my personal history have some thoughts on possible theory. I have no medical background what so ever. But find the human body very intrigging. We only know so little.

    Mastcells can be found in places in body that connects with outside world e.g. lungs and gi
    And are located in nerves system e.g. near blood brain barrière.

    Mastcell (mc) activation due to allergic reaction/ genetic disposition/vaccination early and or later in life. This process leads to permeability of vascular systeem and BB barriere. Maybe we have weak vascular/endothelial system (genetics). And risk for permeability is high. Add on virusses and stress. Our immunesystem is pressured to maintain high performance. It needs atp and thus mitochondria function is working over hours.

    When mc activated by immunesystem it releases amongst others cytokines, histamine and vascular endotholial growth factor (vegf). This allows for permeability of the vascular system including bloodbrain barriere.

    Mitochondria is in mastcell. So the problem starts when after activation of MC mitochondria dna get released into blood. Normally not supposed to happen. Recent studies show this to happen in cancer patients after chemo, auto immune diseases and autism.This triggers inflammation. The BB bariere shows cracks , materials of immunesystem enter the brain and inflammation brain occurs. Nerves system starts producing cytokines and toxins in body. This triggers MC degranulation and again cytokines are realesed. A continious cycle of action and reaction is set in place. Meanwhile brain is impacted, autoimmune reaction is triggerd. Maybe autoimmuun bodies to mitochondria functioning due to leaking of mitochondria dna. In conclusion the body thinks infection is still going on.
     
  17. Zara

    Zara

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    Forgot to ad some sources
    More to find when googling mitochondrial dna, serum....

    Researchers
    1. Nguyen T, et al. Asian Pac J Allergy Immunol. 2017.
    Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients.

    2. Dr. TC Theoharides: mastcell activation, braininflammation, mitochondrial dysfunction, autism. See http://mastcellmaster.com

    3. Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases [version 1; referees: 3 approved] Ray K. Boyapati1,2, Arina Tamborska1, David A. Dorward1, Gwo-Tzer Ho https://orcid.org/0000-0002-6014-372X

    4. Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children. Zhang B, et al. J Neuroinflammation. 2010.
     
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  18. Zara

    Zara

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    When thinking about autism and me/cfs...what are similarities in symptoms and behaviour?
    -High sensitivity to sound,light, smell, touch..
    -brainfog, concentration problems, problem learning new thinks.
    - low energy
    - foodintolerence, gi problems
    - quickly stressed out...agitation..
     
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  19. Learner1

    Learner1 Professional Patient

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    @Zara Thanks for posting. There definitely are some commonalities.
     
  20. wastwater

    wastwater Senior Member

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    Just looked at Martin pall works some interesting bits he thinks NF-kappaB is important (nmda,trp)
    He wrote a paper on glaucoma
    Thinks vitamin D important
    And benzene in gulf war syndrome may be implicated
     
    Last edited: Dec 9, 2017 at 12:16 PM

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