The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
Discuss the article on the Forums.

A 50,000 Foot Overview of Major ME/CFS Theories

Discussion in 'General ME/CFS Discussion' started by Jesse2233, Nov 15, 2017.

  1. Rossy191276

    Rossy191276

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  2. Murph

    Murph :)

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    Yes. I wanted to make sure Armstrong and McGregor weren't overlooked. And their associated clinician, Dr Lewis.

    They are probably too scientific to just have one pet theory but you could say maybe gut dysbiosis combined with genetic susceptibility leading to metabolic disruption of a sepsis type?

    (it's also worth mentioning their fecal microbiome collaborator who end up in some of their studies, Dr Butt. The poop specialist! Not a joke, that's his real name.)
     
  3. Gingergrrl

    Gingergrrl Senior Member

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    Thanks for making me laugh and I am easily entertained by stuff like this. Where is the poop emoji when you need it?!
     
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  4. Jesse2233

    Jesse2233 Senior Member

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    I agree that these can all see pretty disparate, but there's a chance many of them could be simultaneously correct (for all / most / or a subgroup).

    Are you ready for this...

    Genetic predisposition (Kerr / Armstrong / McGregor) leads to suboptimal liver function (@mariovitali) as well as a propensity toward gut dysbiosis and inflammation (KdM) which can be triggered by a variety of pathogens / environmental insults (Chia / Hyde / Ramsay / Jardin / Nicholson / Lerner / Montoya / Cutler / Weir / Miktovas / Shoemaker / Brewer) creating a mystery molecule (Fluge + Mella / R. Davis) that sustains chronic immune dysfunction (Scheibenbogen / M. Davis / Behan / @necessary8 / @Jonathan Edwards) which in turn impairs cellular activity in a variety of ways (Myhill / Pall / F. Davis / Van Kronenburg) causing brain dysfunction (Goldstein) all within the context of a stuck molecular response to trauma (Naviaux).
     
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  5. ivorin

    ivorin Senior Member

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    @Jesse2233 now that puts another light to the whole thing :D
     
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  6. wastwater

    wastwater Senior Member

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    I liked the use of colours
     
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  7. Gemini

    Gemini Senior Member

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    Jay Levy--chronic immune system activation (1980-90's)
    Nancy Klimas--natural killer cell (NK) dysfunction
    Anthony Komaroff--low-grade encephalitis
    G. Lange--acquired brain injury (ABI), functional not structural

    Nice list @Jesse2233! Like the simple sentence format!:thumbsup:
     
    Last edited: Nov 16, 2017
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  8. Learner1

    Learner1 Professional Patient

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    Of course!;)
     
    Last edited: Nov 16, 2017
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  9. Gemini

    Gemini Senior Member

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    The ultimate "holistic systems biology model"!!!:balloons:

    Thanks @Jesse2233!
     
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  10. alex3619

    alex3619 Senior Member

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    This is a burning question that has bugged me for years. Lots of researchers come up with subgroups, but are these subgroups stable for all of the research? Do different responses in post exercise hormones match the subgroups from other causes? It would seem it should be answerable, but nobody has done it.
     
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  11. Gingergrrl

    Gingergrrl Senior Member

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    I would love to know more about the sub-groups, too. Both as far as triggers of the illness and how symptoms present (or differences on blood work).
     
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  12. halcyon

    halcyon Senior Member

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    John Richardson - persistent enterovirus infection
    Elizabeth Dowsett - persistent enterovirus infection
    James Mowbray - 3 subgroups; 1) persistent enterovirus infection, 2) persistent EBV activation, 3) unknown etiology
     
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  13. halcyon

    halcyon Senior Member

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  14. Murph

    Murph :)

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    That is all perfectly logical! But I think we want some research to be dead ends. We need more theories to be falsified so we can chuck them out and zero in on those that remain...
     
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  15. Gemini

    Gemini Senior Member

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    Dharam Ablashi--Reactivation of HHV-6
    Robert Suhadolnik--Upregulated 2-5A Synthetase RNase L antiviral pathway
    David Bell & DH Streeten--Orthostatic Hypotension and Low Blood Volume
    Alan & Katherine Light--Gene expression: sensory, adrenergic, and immune after exercise
     
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  16. dreampop

    dreampop Senior Member

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    This is pretty misleading for some of these researchers, research focus or treatment focus ≠ theory. As someone said in the symposium, they all are touching a part of elephant and so they necessarily talk about that side of it, while knowing it's only a piece in the puzzle.
     
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  17. Jesse2233

    Jesse2233 Senior Member

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    That's a fair point. Just because a researcher / doctor is focused on one area doesn't mean they are necessarily blind to others
     
  18. Gemini

    Gemini Senior Member

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    EM Tan-- Identification and characterization of autoantibodies (1996)
    Mark Demitrack-- Impaired activation of the hypothalamic-pituitary-adrenal(HPA) axis (1991)
    Elaine DeFreitas--Association between an HTLV-II-like retrovirus and ME/CFS (1991)
    LO Simpson-- Altered red blood cell shape, inadequate oxygen delivery, and impaired capillary blood flow(1993)
     
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  19. Mel9

    Mel9 Senior Member

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    Goodness! No wonder I'm confused
     
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  20. Gemini

    Gemini Senior Member

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    Sidney Grossberg-- JHK virus infection (1993)
    Hugh Fudenberg-- persistent antigenic stimulation by dead, incomplete, or latent viruses (1993)
    Paul Cheney--chronic, immunologically-mediated inflammatory process of the CNS (1992)

    @Jesse2233 Paul Cheney has a system's perspective perhaps influenced by his physics background.
     
    Last edited: Nov 19, 2017

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