A Little Poisoning Along the Road to ME/CFS
Looking at my symptoms, many of which are far less these days and some are gone, it would be easy to figure that I'd just been dealing with some heavy-duty menopausal issues.
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8-hydroxy-2' -deoxyguanosine (8-OHdG)

Discussion in 'Post-Exertional Malaise, Fatigue, and Crashes' started by pemone, Jun 7, 2014.

  1. pemone

    pemone Senior Member

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    8-OHdG is thought to be a biomarker of oxidative stress in the body, and has been measured higher in CFS patients. This is a marker that would show if you are producing a lot of free radicals that are not being contained by antioxidants. Since CFS patients generally have poor ability to regenerate NAD+ from NADH, they end up metabolizing NADH in the mitochondria in a way that creates a lot of free radicals.

    Does anyone know a lab in the US that provides this test? What does it cost?

    http://www.ncbi.nlm.nih.gov/pubmed/19412858
     
  2. PDXhausted

    PDXhausted Senior Member

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    NW US
    This is included in Metametrix's organic acids test. You can order the test without a doctor from mymedlab.com.

    Mine was high when I took it. Their recommendation if high is to take vitamins C and E and lipoic acid.
     
  3. pemone

    pemone Senior Member

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    I think Genova has renamed this as the "ION Profile with 40 Amino Acids"
     

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