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7 years gone in vain.... 23andme Results help ??

Discussion in 'Genetic Testing and SNPs' started by ramkishore, Jun 23, 2014.

  1. zzz

    zzz Senior Member

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    The most common cause for high K and Mg readings is serious kidney problems. This is also a major cause of high Na readings, and can be a cause of high Ca readings.

    Possibly because your kidneys may be having major problems, which would cause all sorts of continuing toxicity effects. Getting your kidneys tested is easy, and may be very fruitful.
     
    victoriana and ramkishore like this.
  2. ramkishore

    ramkishore

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    @caledonia

    We see load of ammonia and sulphites there. So the further methyl groups that come still go through CBS and create even more ammonia and sulphur.

    So I understand the problem being created due to further methyl groups but still we are not stopping methly groups from entering into CBS pathway like the BHMT activity could be slowed down by taking DMG(not sure of the name) I hope I am right in asking this question. I will keep me eye on this question for a long time because this enzyme activity killed almost 7 years of my life.

    I found few courses being offered at edX which help you with all genomic stuff for beginners.

    Thanks for the help.
     
  3. caledonia

    caledonia

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  4. ramkishore

    ramkishore

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    @caledonia
    I did order Calcium d glucarate of Source Naturals as I have problems with SUOX/CBS. I do have high estrogen. way high.

    How should I go about CYP26D and GSTP?



    I read roadblocks to successful Methylation pdf. I don't know how to Thank you. Honestly.
     
  5. ramkishore

    ramkishore

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    @caledonia

    Questions regarding supplements usage from "Roadblocks to successful Methylation"

    1. You sugggested Potassium gluconate. I have Potassium citrate bottle already. Is it a good substitute?
    2. Similarly, I have activated charcoal. Is it good substitute to charcoal?

      I have magnesium glycinate/lysinate chelate instead of magnesium citrate . Is that ok?
    3. Are these forms of Molybdenum ,Manganese ok?
      Molybdenum (as molybdenum amino acid chelate)(http://www.iherb.com/Country-Life-Gluten-Free-Molybdenum-Chelated-150-mcg-100-Tablets/15298)
      Manganese (as manganese glycinate amino acid chelateā€ )( http://www.iherb.com/Solgar-Chelated-Manganese-100-Tablets/48554)
    4. we see L-5 Methyl THF and 5 Methyl THF. Are they same?

    Thanks once again Caledonia.God Bless.
     
  6. brenda

    brenda Senior Member

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    @ramkishore

    If you think that you are on the autistic spectrum, as I have recently discovered for myself, you might find that the forums for parents of autistic kids to be of use, such as this one:

    http://www.autismweb.com/forum/viewforum.php?f=4&sid=d80b0e3ad5d041b9b09e2614f906c0e1

    One thing that I have discovered which I think is being of some use, is that those on the spectrum are often deficient in thiamine b1 but it needs to be in a bioavailable form otherwise it is not absorbed very well. These mothers of autistic kids will move heaven and earth to help their kids and some of them are very knowledgeable about what helps.

    ps mercury in your hair shows that you are detoxing it. What is your diet and are you on any medications?
     
    taniaaust1 likes this.
  7. caledonia

    caledonia

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    CYP2D6 - just be careful of the meds in that pathway. If you need to take one of them, start with a smaller dose to test the waters.

    GSTP - doing methylation treatment will automatically create glutathione, and should be sufficient. You could possibly supplement with glutathione directly, but some people have problems tolerating it. If you do decide to supplement with glutathione, Ben Lynch says to take NAD with it so it will make the good reduced glutathione and not the bad oxidized glutathione.
     
  8. caledonia

    caledonia

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    I think all of those supps would ok. L-5 Methyl THF and 5 Methyl THF are the same. Heartfixer suggests 75mcg for molydenum, so that would be 1/2 of a pill.
     
  9. ramkishore

    ramkishore

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    @brenda


    Many thanks Brenda. supplement ordered. Really helpful pointer.
    Thanks once again.
     
    victoriana likes this.
  10. taniaaust1

    taniaaust1

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    As ME/CFS research isnt well funded, I dont know if there has been any studies at all done with us and based on methylation issues found based on gene testing.

    You could try to do a search at pubmed (it has all the medical studies published there).
     
  11. ramkishore

    ramkishore

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    @caledonia

    it took quite a time to order these supplements to india and finally after 1 week at customs, they are here at my desk and i have to start taking them according to genetic mutation.

    Now Foods, GABA, 500 mg, 100 Capsules

    Doctor's Best, Best L-Carnitine Fumarate, 855 mg, 60 Veggie Caps

    Source Naturals, Pantothenic Acid, 100 mg, 250 Tablets

    Solgar, Vitamin B2, 50 mg, 100 Tablets

    Jarrow Formulas, Liquid Carnitine, Lemon-Lime Flavor, 16 fl oz (475 ml)

    Now Foods, Potassium Gluconate, 100% Pure Powder, 1 lb (454 g)

    Solgar, Folate As Metafolin, 800 mcg, 100 Tablets


    Doctor's Best, Best D-Ribose, 850 mg, 120 Veggie Caps

    Now Foods, Magnesium Citrate, 120 Vcaps

    Now Foods, Beta Carotene, 25,000 IU, 250 Softgels

    Country Life, Gluten Free, Molybdenum, Chelated, 150 mcg, 100 Tablets

    Now Foods, Yucca, 500 mg, 100 Capsules

    Anabol Naturals, Dibencoplex 10,000, 30 Sublingual Tablets

    Enzymatic Therapy, B12 Infusion, Energy, 30 Chewable Tablets

    Nature's Way, Niacin, 100 mg, 100 Capsules

    Benfotiamine Inc., Benfotiamine-V, 150 mg, 120 Veggie Caps

    NutraMedix, Sparga, Sulphur Detox, 1 fl oz (30 ml)

    Solgar, Chelated Manganese, 100 Tablets

    Jarrow Formulas, Yaeyama Chlorella, 3.5 oz (100 g) Powder



    I am going according to the rules laid by @caledonia in the document 18 Roadblocks to methylation.


    Step 1 is to remove ammonia and sulphates from the body.

    how often do i take charcoal to remove ammonia?

    To handle sulphates i will take molubdenum after breakfast the dose of 75ug. hope that is fine?

    Secondly the sulpha detox product:

    www.iherb.com/NutraMedix-Sparga-Sulphur-Detox-1-fl-oz-30-ml/55337

    when should I take this?


    And how long should i do this ammonia and sulphur treatment?

    warm Regards
     
    victoriana likes this.
  12. caledonia

    caledonia

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    I went back and reviewed your posts. Is getting stool testing is impossible for India?

    As far as ammonia and sulfur. You can use the sulfate strips linked in my signature to see how much sulfur you have. As you do treatment, the sulfur levels should go down. When they're under 800, then you're done. I've heard estimates of 4-8 weeks. It took me 12 weeks.

    I haven't heard of any specific time of day to take molydenum. The dose is ok.

    I'm not familiar with the sulfa detox product.
     
  13. ramkishore

    ramkishore

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    Very good to read your post again.

    So far I tried in many hospitals with no luck at all. Docs never heard of those stool tests. I will keep trying.

    I am sure I will reach those sulphur levels way soon. Its already 2 weeks gone I used those molybdenum tabs.

    I will update you with the results.

    Thanks once again for time taken Caledonia.
     
  14. caledonia

    caledonia

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    A hospital or regular type of doctor is not likely to know what those tests are. You need to find an alternative or holistic type of practitioner, either a naturopath or functional medicine doctor.
     
  15. ramkishore

    ramkishore

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    @caledonia

    I ordered the strips as you said.
    After 3 weeks I was able to manage to get my sulphate strips show reading of >400 and less than 800.

    So the next step would be to go testing ammonia levels?
    which test to take? any home test strips can be done?

    Thanks in advance.
    Still a long road ahead for me.
     
  16. caledonia

    caledonia

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    The only way to do ammonia is with a blood test. I don't know if it's something a regular doc can do. It is part of the Nutreval test, which is very comprehensive, but expensive - but good to do if you can manage it.

    If you've done the full CBS protocol, your ammonia should be out too, I think.

    Heartfixer says to continue on the CBS supps for another month. In the meantime, you can start to introduce supps for MTHFR and MTR/MTRR, i.e. methylfolate and B12.

    See the link to the Heartfixer in my signature below for complete information about the CBS protocol.
     
    ramkishore likes this.
  17. ramkishore

    ramkishore

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    @caledonia

    Hi Caledonia and others. How are you doing?

    My Update:

    I stopped taking protein for quite some time.

    Test Results:

    Ammonia 8.2 micro mol/L 11.0 - 32.0
    Sample :Blood EDTA
    Method : van Anken and Schiphors

    * Folic Acid 13.01 ng/ml 3.00 - 17.00
    Sample :Serum
    Method : CLIA
    * Vitamin B12 624 pg/ml 211.00 - 911.00
    Sample :Serum
    Method : CLIA

    Before going ahead with b9 and b12 i got this tests. they are ok according to the results.

    Do I still need to take b9 and b12?

    Anyways I started taking them since last 4 days. On the fifth day, my left hand started shaking involuntarily. I was scared for a moment. I will post this question on the main forum too.

    Regards
     
  18. caledonia

    caledonia

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    The serum B12 test is more or less useless. If it's low you're deficient, but if you're normal like yourself (and me) or even high, you can still be deficient.

    The same is true of a serum folic acid test. Mine was normal, but my folic acid RBC was low. RBC = red blood cells

    The important thing is what is getting into the cells and not what's floating around in the bloodstream. You have to do the right tests.

    As for your shaking hand - possibly low potassium? That can come on rapidly depending on how high the dose of supplements is. Low magnesium is another possibility. (or both) A deficiency in those can cause muscle twitching/spasms/cramps.

    Did you discontinue the supplements and did the shaking go away?

    How many mcg of methylfolate and B12 were you taking?
     
  19. ramkishore

    ramkishore

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    Ok I will do folic acid RBC now.

    I do have mercury fillings.
    I am taking 1mg of mb12 jarrow brand and 400ug methylfolate of solgar brand.
    I am continuing this supplements and the shaking did not return so far but I do feel completely different in the body.

    I will start with potassium and magnesium and let you know.

    when should I add acetly-carnitine and d-ribose?
    How should I dose up mb12 and metlhylfolate?

    I feel very fatigued while taking these supplements.


    Thanks in advance
     
  20. caledonia

    caledonia

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    The mercury can make you feel worse as it's coming out. My symptoms are extra tired and flu like aches. I could see the hand shaking being caused by this too. Mercury can cause neurological symptoms.

    What I did was cut back to extremely small doses so I didn't feel bad while the mercury was detoxifying. The doses you're taking are high. Those are final doses, not starting doses.

    See my document Start Low and Go Slow for ideas on how to cut the pills down. There is one other method, I haven't put in the document yet, called the Wet Toothpick Method. Crush the pill into powder, dip the end of a wet toothpick in it, and just pick up a little bit.

    It would be best if the mercury fillings came out and were replaced with something non toxic. There is a right way and a wrong way to do this, as you can get dosed with even more mercury when they're taken out. You want to minimize your exposure. If you decide to get them taken out, do your research.

    I think it would be ok (and even preferable) to continue with methylation, and then gradually over time, get your mercury fillings out. Then once they're finally out, it may be another 6 months before all the mercury comes out of your fat stores. You may need to keep your supplementation extremely low while all this is going on so you don't feel too bad.

    I wouldn't add acetyl L carnitine, etc. until you get the folate, B12, and magnesium and potassium levels all worked out.
     
    ramkishore and Gondwanaland like this.

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