Interesting, dr jay goldstein has written that ketamine as one of the most useful treatments for cfs/me. Another thing i have read in the past that is interesting was that depression treatment resistant patients have responded well to tramadol which not only acts like some antidepressants but also on opiate receptors, maybe also has effects on glutamine. The problem with these meds is that the general public and unknowledgable medical people would be raving on about being drug addicts if these meds were used for treatments outside their current indication. Sometime i think the do gooders of the world think they are trying to do good but know very little on what they are trying to improve or think they can improve. This might also be the problem with why xyrem is so hard to get approved for cfs/me sleep problems, because it will turn us all into drug addicts, dont mind that it will improve our ability to function and correct a medical disorder that can be measure by a sleep study?? cheers!!!