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50% reduction in breast and prostate cancer in people with HIV on antiretrovirals

Discussion in 'XMRV Research and Replication Studies' started by Bob, Jun 2, 2011.

  1. Bob

    Bob

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    Here's an interesting article saying that there is a 50% reduction in the incidence of breast and prostate cancer in people with HIV on antiretroviral therapy.

    Letter to the Lancet:

    Mouse viruses and human disease
    Alexandre FR Stewart, D William Cameron
    http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(11)70082-2/fulltext#


    Extra info from the article:
    "Researchers from several laboratories have identified DNA sequences highly homologous to the mouse mammary tumour virus (MMTV; a betaretrovirus of mice) in about 40% of human breast cancer specimens"


    It's interesting that 40% is the same proportion in which they are finding XMRV in prostate cancer patients.
     
  2. Jemal

    Jemal Senior Member

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    Yep, to me it looks like more evidence mouse retroviruses could be amongst us.
     
  3. Enid

    Enid Senior Member

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    Very interesting find Bob - gets one thinking about all the viruses in the "arena" now and antiretroviral benefits.
     
  4. Bob

    Bob

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    Judy now says she has detected the following MLV-related HGRV's:
    Friend Virus
    spleen focus forming virus
    DG-75

    And then there's the 'contamination' from GaLV that the CDC found in DeFreitas' samples. GaLV is very similar to MLV's.
    (GaLV = gibbon ape leukemia virus.)
    Strange how they are now looking for GaLV in monkeys to see if that's where XMRV could have originated.

    It does make one wonder!
     
  5. Jemal

    Jemal Senior Member

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    I am thinking the ride isn't over yet... it has been quite bumpy so far, though :D
     
  6. Enid

    Enid Senior Member

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    Reminds me when very ill at 2000 hearing eminent biologists (can't remember which) saying this will be the century of the virus. We would hope faster but looks well on the way.
     
  7. Jemal

    Jemal Senior Member

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    Yes, I remember those words as well (I tried to Google them yesterday, but found no source). This will be the century of the virus and they are right I think.
     
  8. jenbooks

    jenbooks Guest

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    Good find, Bob, thanks.
     
  9. currer

    currer Senior Member

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    Aren't these Robin Wiess's Rumour viruses?
     
  10. Bob

    Bob

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    Which ones? Do you mean the ones that Judy is finding?
     
  11. anciendaze

    anciendaze Senior Member

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    There are conflicting reports over that contamination at the CDC: GaLV and MuLV. No source for the contamination was ever traced, yet the CDC developed an exceptionally sensitive test for mouse contamination.
     
  12. currer

    currer Senior Member

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    Ha! - Yes he would like that!

    No - the mouse mammary tumor virus - I dont think that finding got very far at the time, either.

    Maybe a lot of people will take courage from the WPI and come out again with their viral findings. I haven't looked into this in detail, but there have been other viral suspects in the past in tumours and they all had problems with reproducability and PCR.
     
  13. liquid sky

    liquid sky Senior Member

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    Those are pretty significant figures, 50% reduction in breast cancer in those on ARV's and 40% of breast cancer tumors being found by multiple researchers to contain mouse virus fragments.

    Sounds like there is a lot to what Judy has been saying about the connection to HGRV's and breast cancer.
     
  14. Bob

    Bob

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    And then there's this:

    Autism Jumps 57% in Just 4 Years
    1 in 110 U.S. Kids Has Autism, CDC Study Confirms
    Dec. 18, 2009 Autism disorders increased by 57% in just four years, the CDC today reported.
    http://www.webmd.com/brain/autism/news/20091218/autism-jumps-57percent-in-just-4-years

    This caught my eye particularly because of what Dr Deckoff Jones said in her letter to the Science editors re the WPI's research into autism...

     
  15. Jemal

    Jemal Senior Member

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    Autism is not an epidemic, they are just developing better diagnostic criteria. At least that's what the government is telling me over here ;)
     
  16. Bob

    Bob

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    I've just remembered that Dr Singh detected XMRV in 25% of breast cancer tissue samples in a study of 178 samples. This is similar to the detection rate of 23% in her prostate cancer study. I don't think that we've heard much about these results though, so I don't know what's happening with this research.

    "The patent application states Dr. Singh has found XMRV in 25% of 178 samples from patients with breast cancer"
    http://phoenixrising.me/?p=1923

    More info:
    http://www.facebook.com/notes/xmrv-...s-on-xmrv-breast-cancer-prostate/472237776796
    http://bodyprinciple.wordpress.com/2010/11/26/dr-singhs-xmrv-patents-now-breast-cancer/
     
  17. redo

    redo Senior Member

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    Great find bob! I am too foggy to read now, but the 50% reduction, is that compared to HIV patients not using ARVs, or compared with healthy controls? If it is the latter, than I really think we're onto something.
     
  18. Bob

    Bob

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    Good question redo...
    I can't be certain because it's not fully explained in the article, but I think it's a comparison to the normal population...
    I think the full research is explained in this paper, which I don't have access to:

    Spectrum of cancer risk late after AIDS onset in the United States.
    Simard EP, Pfeiffer RM, Engels EA.
    http://www.ncbi.nlm.nih.gov/sites/e...tern Med[Jour] AND 170[Volume] AND 1337[page]
     
  19. Bob

    Bob

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    Two different retroviruses found in breast cancer.

    Dr Singh is reported to have found XMRV in 25% of 178 breast cancers samples.

    Other studies have detected retrovirus sequences "highly homologous to the mouse mammary tumour virus (MMTV)" in 40% of breast cancer samples.


    The detection rate for MMTV in the breast cancer studies is the same (40%) for some of the studies that detected XMRV in prostate cancer samples (I think - I'm not certain of the details without double-checking). I wonder if this is simply a coincidence.

    And I wonder if Judy has detected any MMTV in any of her samples? Except that MMTV is a beta retrovirus, and Judy is looking at gamma retroviruses.

    It's very interesting.


    ---------------------------------------------------

    Dr Singh's XMRV results:

    "The patent application states Dr. Singh has found XMRV in 25% of 178 samples from patients with breast cancer"
    http://phoenixrising.me/?p=1923

    More info:
    http://www.facebook.com/notes/xmrv-...s-on-xmrv-breast-cancer-prostate/472237776796
    http://bodyprinciple.wordpress.com/2010/11/26/dr-singhs-xmrv-patents-now-breast-cancer/

    ---------------------------------------------------

    MMTV:

    Mouse viruses and human disease
    Alexandre FR Stewart, D William Cameron
    http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(11)70082-2/fulltext#

    "Researchers from several laboratories have identified DNA sequences highly homologous to the mouse mammary tumour virus (MMTV; a betaretrovirus of mice) in about 40% of human breast cancer specimens"

    ----------------------------------------------------
     
  20. In Vitro Infidelium

    In Vitro Infidelium Guest

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    http://archinte.ama-assn.org/cgi/content/short/170/15/1337

    The key thing to know would be the age profile of the two study populations , but there are numerous confounding factors and while a 50% reduction is signficant, the total occurrences of breast and prostate cancers in the two populations may actually be quite small.

    IVI
     

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