Has anyone else had this problem with 5-HTP? I've tried taking 5-HTP many times of the last few years and every time it works for the first day or 2 (immediate, drastic mood lift), then stops working completely. It's like some nutrient becomes depleted. The nutrients needed to convert 5-HTP to Serotonin are: Vitamin B6 Vitamin C Zinc Magnesium I supplement all these. I take a b complex (also extra P5P in the 5-HTP caps), 50mg zinc picolinate, 4.5g magnesium ascorbate, 250mg of magnesium oil (transdermal). I suspect my digestive tract is just too screwed to absorb them.