I've been grinding some metal logic in the last couple of days and reflecting on what I've achieved over nearly 6 years of ME. Gone are the 22 hours sleep under a lead balloon. We are not only waiting for a cure but waiting for a definite pathogenesis for ME. We are still waiting but everybody on this forum is trying to get better, experimenting in their own way. I started experimenting with antibiotics after the first 6 months having contemplated suicide, having wished for a cancer diagnosis so at least they could operate, give me chemo, give me a fighting chance.... As a state registered specialist biomedical scientist I undertake mostly lab rat work, but we still experiment. We read science papers and we use LOGIC. So I'll throw this out to the community- I reached the conclusion early on that my brain was being damaged, why else couldn't I spell my name? What was causing me to shiver, slur my words like a drunk, give me headaches, make me intolerant of sound? It took me a little while....but I figured there was brain inflammation: see the link for Kansai Osaka university's PET scan imaging of inflamed areas of ME patients' brain here http://jnm.snmjournals.org/content/early/2014/03/21/jnumed.113.131045.full.pdf What is the number go to King of anti inflammatories? Prednisolone steroid I wandered through neurology texts, watched youtube programmes and learned that the brain is incredibly plastic, generating neurons and forging new neural pathways. The logic comes in...your brain is damaged so attempt to promote neurogenesis. How ? Nootropics. I was initially nervous about taking noots but did a month of research prior to dipping my grey matter in traditional brain stimulating herbs such as vinpocetine, huperzine A, bacopa monnieri, lion's mane mushroom. No ill effects, so I made the decision to try Noopept (pharmaceutical name GVS-111) dosed with the choline source Alpha GPC. Then, the improvements began with a falling off of postural hypotension, less brain fog. It is now my fourth year of pulsing Noopept 2 weeks on 2 weeks off. I believe my brain has re-wired somewhat. (It should be noted that I have consistently taken up to 20 other tablets a day, the normal stuff we do with ME) The recent work from this year's Invest in ME illustrates potential of gut microbiome disturbances. I related my experiences in Ayurvedic medicine on the blog (panchakavya- microbiome ) and a recent experiment I undertook. Probiotics may play a role in helping us fight ME. So there it is, the 3 Kings Steroids Nootropics Probiotics Not the cure I need or want but perhaps a highly significant helping hand. I am not a lead balloon. I worked 3 days in the lab this week.